processes Endothelial fenestrae Elsevier items and derived items e 200 by Mosby, Inc, an affiliate of Elsevi
Foot processes Endothelial fenestrae
Glomerular filtration barrier NSCC ng TRPC6 Podocin FAK a-Actinin 4 Nephrin NEPH 1 B1 Laminin P-Cadherin FAT Dystroglycan Integrin Q COLLAGEN IV (a3, a4, as) Mod ed from Endlich K Kriz w, witzgall R Update in podocyte biology. Curr Opin Nephro 200110:331-340
Size and charge barrier Normal kidney 875 a50 Neutral molecules Effective molecular radius(nm) Loss of fixed negative charges 。75 Effective molecular radius(nm) sevier items and derived items 0 2007 by Mosby, Inc, an affiiate of Elsevier Inc
Tubular epithelia Luminal Paracellular Transcellular membrane transport transport Tight junction Basolateral Lateral membrane intercellular space Basement membrane Elsevier items and derived items e 2007 by Mosby, Inc. an affiliate of Elsevier Inc
Renal autoregulation 5 Mechanisms Celluar. calcium channels No, Kinins. RAS yogenIC: vascular wall tension 3 Tubuloglomerular Renal blood flow feedback (TGF Glomerular filtration rate Metabolic: vasodilator metabolite as adenosine ADP ATP L 200 Mean arterial pressure(mm Hg) sevier items and derived items 02007 by Mosby, Inc, an affiliate of Elseviar Inc
Mechanisms Celluar:calcium channels, NO, Kinins, RAS Myogenic: vascular wall tensioin Tubuloglomerular feedback (TGF) Metabolic: vasodilator metabolite as adenosine, ADP, ATP