√Stable tissues Divide infrequently (usually in GO phase) o i.e.,hepatocytes,astrocytes,smooth muscle cells May be stimulated (GF)to enter the cell cycle,and undergo hyperplasia or hypertrophy as an adaptation
Stable tissues Divide infrequently (usually in G0 phase) i.e., hepatocytes, astrocytes, smooth muscle cells May be stimulated (GF) to enter the cell cycle, and undergo hyperplasia or hypertrophy as an adaptation
√Permanent tissues i.e.,neuron,skeletal and cardiac muscle cells May undergo hypertrophy (muscle only)
Permanent tissues i.e., neuron, skeletal and cardiac muscle cells May undergo hypertrophy (muscle only)
Role of the Extracellular Matrix in Tissue Repair o sequestering water o providing turgor to soft tissues,and minerals giving rigidity to bone o regulates the proliferation,movement,and differentiation of the cells living within it supplying a substrate for cell adhesion and migration o serving as a reservoir for growth factors
Role of the Extracellular Matrix in Tissue Repair sequestering water providing turgor to soft tissues, and minerals giving rigidity to bone regulates the proliferation, movement, and differentiation of the cells living within it supplying a substrate for cell adhesion and migration serving as a reservoir for growth factors
Extracellular matrix o Two basic forms of o Three basic components ECM 1.Collagens and elastins 1.Basement membranes 2.Proteoglycans and hyaluronan 2.Interstitial matrix 3.Adhesive glycoproteins
Extracellular matrix Three basic components 1. Collagens and elastins 2. Proteoglycans and hyaluronan 3. Adhesive glycoproteins Two basic forms of ECM 1. Basement membranes 2. Interstitial matrix
Epithelium Integrins Fibroblast BASEMENT MEMBRANE Integrins Type IV collagen Endothelial cells ◆Laminin Adhesive Proteoglycan glycoproteins Capillary 瓶欢 -Int egrins 孩封 Fibroblast Pr oteoglycan INTERSTITIAL MATRIX ·Fibrillar collagens Type IV collagen- ·Elastin -Cross-linked Proteoglycan and Laminin- Proteoglycan collagen triple helices hyaluronan The major components of the extracellular matrix(ECM)
The major components of the extracellular matrix (ECM)