Mechanistic toxicological research ❖ Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular level. ❖ It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship (SAR) can be developed further
Mechanistic toxicological research ❖ Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular level. ❖ It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship (SAR) can be developed further
Revision of chemical education ❖ The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed. ❖ Separated mode of education traditionally ❖ Although the function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists, pharmacologists, bio-chemists and others, it is believed that individuals with a combined knowledge of chemical structure, industrial application and biological activity at the molecular level will perform more efficiently and effectively
Revision of chemical education ❖ The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed. ❖ Separated mode of education traditionally ❖ Although the function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists, pharmacologists, bio-chemists and others, it is believed that individuals with a combined knowledge of chemical structure, industrial application and biological activity at the molecular level will perform more efficiently and effectively
Industrial efficacy of chemicals Industrial synthesis chemist Traditional Industrial educational mode Medical and pesticide chemists Pharmacological, Biochemical, Toxicological effects (SAR） Traditional Pharmacological educational mode New hybrid Green chemist A comparison of the traditional educational mode and the new mode needed for cultivation of hybrid chemist
Industrial efficacy of chemicals Industrial synthesis chemist Traditional Industrial educational mode Medical and pesticide chemists Pharmacological, Biochemical, Toxicological effects (SAR） Traditional Pharmacological educational mode New hybrid Green chemist A comparison of the traditional educational mode and the new mode needed for cultivation of hybrid chemist
Revision of chemical education ❖ The new hybrid chemist or the toxicological chemist or simply green chemist must consider both the function of the chemical in its industrial or commercial application and its toxicological effects in humans and the environment
Revision of chemical education ❖ The new hybrid chemist or the toxicological chemist or simply green chemist must consider both the function of the chemical in its industrial or commercial application and its toxicological effects in humans and the environment
Chemical industry involvements ❖ Major support and participation by the chemical industry is essential. ❖ Industry must take steps to increase the awareness of the concept among its scientists and management. ❖ Industry must encourage its people to approach the concept with open minds and to carefully evaluate its potential in terms of economic and technical feasibility
Chemical industry involvements ❖ Major support and participation by the chemical industry is essential. ❖ Industry must take steps to increase the awareness of the concept among its scientists and management. ❖ Industry must encourage its people to approach the concept with open minds and to carefully evaluate its potential in terms of economic and technical feasibility