ORGANIC CHEMISTRY Chapter 12 12. 7 Reactions of Organolithium and Organomagnesium Compounds Department of Chemistry, Xiamen University
ORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 12 12.7 Reactions of Organolithium and Organomagnesium Compounds
ORGANIC CHEMISTRY Chapter 12 12.7A Reactions with Compounds Containing Acidic hydrogen Atoms o Grignard reagents and organolithium compounds are very strong bases. They react with any compounds that has a hydrogen attached to an electronegative atom such as oxygen, nitrogen, or sulfur HOH RH HO+ Mgt+X ROH RMgX RH+RO Mg+ X R'C≡CH RH+RC≡CMgx δ-8 RLi+RC≡CH—-RH+RC≡CL Department of Chemistry, Xiamen University
ORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 12 12.7A Reactions with Compounds Containing Acidic Hydrogen Atoms Grignard reagents and organolithium compounds are very strong bases. They react with any compounds that has a hydrogen attached to an electronegative atom such as oxygen, nitrogen, or sulfur. RMgX R'C CH HOH R'OH RH RH RH + + + HO + Mg2+ + X R'O + Mg2+ + X R'C C MgX δ− δ+ RLi + R'C CH R'C C Li δ− δ+ RH +