F-actin 3D reconstruction of 3D reconstruction F-actin filaments Electron-micrograph of containing negatively stained F-actin Model of an F-actin of an F-actin tropomyosin, filamentin which each filament from filaments an elongated protein sub-unit is depicted as muscle. which binds along the a sphere. actin helix
3D reconstruction of an F-actin filament from muscle. 3D reconstruction of F-actin filaments containing tropomyosin, an elongated protein which binds along the actin helix Model of an F-actin filament in which each sub-unit is depicted as a sphere. Electron-micrograph of negatively stained F-actin filaments. F-actin
(三)微丝 结合蛋白 微丝结合蛋白 (microfilament associated protein 参与形成微丝纤维 高级结构,对肌动 Myosin structure 蛋白纤维的动态装 ATP Binding 配有调节作用 Neck Domain 1肌肉收缩系统中的 Regulatory 有关蛋白 肌球蛋白( myosin Actin 3 Binding Regio Motor Domain Light cha
微丝结合蛋白 （microfilament - associated protein ） 参与形成微丝纤维 高级结构，对肌动 蛋白纤维的动态装 配有调节作用。 1.肌肉收缩系统中的 有关蛋白 肌球蛋白（myosin ） （三） 微丝 结合蛋白 Myosin structure
II The Myosin‖ molecule r5 Globular head domain Coiled coil tail Proteolysis h Staphlococcus Aureas Protease three of the most widespread myosin classes in cartoon ant or S1 form motor domains are shown in red, light chains in Heavy MeroMyosin yellow and a-helical coiled coils in green. Other domains shown may be involved in cargo binding or localisation
three of the most widespread myosin classes in cartoon form. Motor domains are shown in red, light chains in yellow and α-helical coiled coils in green. Other domains shown may be involved in cargo binding or localisation
Tropomyosin molecules Troponin molecules Actin molecules Tropomyosin Troponin Thin filamen Thick filament groups molecules) filament 8889乘 osin molecule Head groups m thick filament) vy meromyosin Light meromyosin Myosin molecule split by papain
Thick Filam opposite orientations ssembly i C terminus chain Phosphory lation Domain osin molecule Cas 2+ Ca/ caM (activation) MLCK my osin (phosphorylation) MLC phosphatase (dephosphorylation) actin