OH H H BOF +oh K=ketone[hI
K = k [ketone] [H+ ] H O H + OH X2 OH X + X O －X - . .OH + X H + H +
Application in organic synthesis e preparation o unsaturated carbonyl group H X B H30 HX
H O X O O X2 B H3O + －HX Application in organic synthesis : the preparation of a,b – unsaturated carbonyl group
Deuterium /hydrogen exchange of carbonyl group reaction DO oH).ot H OH) OH()-D D D 一H(D) D
a-Deuterium / hydrogen exchange of carbonyl group reaction: D + OH(D) O D + OH(D) D OH(D) H O . . D3O + D3O + D + H(D)+
P347 0:H DO OH) C6HsCC-CH5 C6H5C-C-CH5 R或S CH3 CH3 DO C6H5C=CDCH5 CH3
P.347 C6H5 CCC2H5 CH3 O H C6H5 CCC2H5 CH3 OH(D) C6H5 C CDC2H5 CH3 O R-或 SD3O + D3O +
Alpha Bromination of Carboxylic Acids The Hell-Volhard-Zelinskii reaction RRCHCO,H+ X P RRCXCO,H P.398 OH P orS R: R RR 0 OH PX R∽C、 .C RR R RR 0 0 0 x OH OH X RR RR R: R RR
Alpha Bromination of Carboxylic Acids: The Hell–Volhard–Zelinskii Reaction PX3 C O X H R R' C OH X R R' C O X X R R' X2 C O OH H R R' X2 P or S C O X X R R' + C O OH H R R' C O OH X R R' + C O X H R R' C O X H R R' RR'CHCO2H X2 RR'CXCO2H P + P.398