All dNA is recombinant dna a Genetic exchange works constantly to blend and rearrange chromosomes, most obviously during meiosis, when homologous chromosomes pair prior to the first nuclear division a During this pairing, genetic exchange between the chromosomes occurs. this exchange, classically termed crossing over, is one of the results of homologous recombination
◼ All DNA is recombinant DNA. ◼ Genetic exchange works constantly to blend and rearrange chromosomes, most obviously during meiosis, when homologous chromosomes pair prior to the first nuclear division. ◼ During this pairing, genetic exchange between the chromosomes occurs. This exchange, classically termed crossing over, is one of the results of homologous recombination
OUTLINE 1. Models for Homologous Recombination(two models*x 2. Homologous Recombination Protein Machines(RecBCD pathway* xK 3. Homologous Recombination in Eukaryotes(meiosis recombination proteins) 4. Mating-Type Switching(a gene conversion event) 5. Genetic Consequences of the Mechanism of Homologous Recombination(exchange or ConversIon
OUTLINE 1. Models for Homologous Recombination (two models)** 2. Homologous Recombination Protein Machines (RecBCD pathway)** 3. Homologous Recombination in Eukaryotes (meiosis recombination, proteins) 4. Mating-Type Switching (a gene conversion event) 5. Genetic Consequences of the Mechanism of Homologous Recombination (exchange or conversion)
CHAPTER 10 Homologous recombination at the molecular level Topic 1: Models for Homologous Recombination 1 Holliday model( Holliday模型) 2. Double-strand break ( dsB) repair model(双链断裂修复模型) 劣溪字 Wuhan University
Topic 1: Models for Homologous Recombination 1.Holliday model (Holliday模型) 2.Double-strand break (DSB) repair model (双链断裂修复模型) CHAPTER 10 Homologous recombination at the molecular level
Key steps shared by different models Alignment(结盟) of two homologous DNA molecules Introduction of breaks in the dna Formation of initial short regions of base pairing between the two recombining DNA molecules, strand invasion Movement of the Holliday junction branch migration >Cleavage of the holliday junction resolution
➢ Alignment (结盟) of two homologous DNA molecules. ➢ Introduction of breaks in the DNA ➢ Formation of initial short regions of base pairing between the two recombining DNA molecules: strand invasion ➢ Movement of the Holliday junction: branch migration ➢ Cleavage of the Holliday junction: resolution Key steps shared by different models
The holliday model illustrates key steps in homologous recombination The Holliday model very well illustrates the dna strand invasion branch migration, and Holliday junction resolution processes central to homologous recombination Watch the animation for details!
The Holliday model very well illustrates the DNA strand invasion, branch migration, and Holliday junction resolution processes central to homologous recombination. The Holliday model illustrates key steps in homologous recombination Watch the animation for details!