Palmitate 16:0 Palmitate is the desaturation Palmitoleate 16:1(△ Precursor for the Stearate 18:0 elongation biosynthesis of desaturation ger saturated Oleate fatty acids 18:1(△9) other fatty acids desaturation (in plants Linoleate 182(△9.12) desaturation desaturation -in plants Y-Linolenate 83(△ 6.9.12 -Linolenate elongation 18:3△9.12.15 Eicosatrienoate 20:3(4811,14) de Other polyunsaturated Arachidonate fatty acid 20:4(△58,114)
Palmitate is the Precursor for the biosynthesis of other fatty acids
CH3-(CH2),-CH2-CH2-(CH2)m-C +O2+2H Saturated S-COA fatty acyl-CoA 2 Cyt bs Cyt bs reductase NADPH (F (FAD) +h fatty acyl- CoA desaturase 2 Cyt bs Cyt bs reductase NADP (FADH2) CH3-(CH2),-CHCH-(CH2)m-C +2H2O Monounsaturated S-CoA fatty acyl-CoA Fatty acyl-CoA is desaturated(oxidized) by O2 and NADPH
Fatty acyl-CoA is desaturated (oxidized) by O2 and NADPH
Oleate can be CHo-0-C desaturated on CH-0 Phosphatidylcholine CH o-P (often attaching to C-2) oleate 18: 1(4") to form linoleate CH2-0—C and linolenate CH-O CHy-O-P-0-CH2-CH2-N(CH3)3 Phosphatidylcholine containing linoleate. 18: 2(4) desaturase CHo-0--C CH-0→ CH2-0-P-0-CH2-CH,-N(CH3)a Phosphatidylcholine containing linolenate,18:3△”121)
Oleate can be desaturated on Phosphatidylcholine (often attaching to C-2) to form linoleate and linolenate
10. Eicosanoids are derived from arachidonate, 20: 4(45, 8, 114) The arachidonate(花生四烯酸) is first cleaved off from membrane phospholipids by phospolipase a2, in response to hormonal or other stimuli o Arachidonate is then converted to PGh, by the catalysis of the bifunctional cyclooxygenase (COX): the cyclooxygenase activity converts arachidonate to PGg2; the peroxidase activity then converts Pgga to Pgh2 o PGH is the immediate precursor of other prostaglandins and thromboxanes
10. Eicosanoids are derived from arachidonate, 20:4 (5,8,11,14) ⚫ The arachidonate (花生四烯酸) is first cleaved off from membrane phospholipids by phospolipase A2 , in response to hormonal or other stimuli. ⚫ Arachidonate is then converted to PGH2 by the catalysis of the bifunctional cyclooxygenase (COX): the cyclooxygenase activity converts arachidonate to PGG2 ; the peroxidase activity then converts PGG2 to PGH2 . ⚫ PGH2 is the immediate precursor of other prostaglandins and thromboxanes