Lthe wall of endothelia is very thin and contains pores,andcoveredbydiaphragm*integratedbasallamina.*tightjunction* distributed in mucosa of digestive tract, glomerulus inkidney and some endocrine glands
* the wall of endothelia is very thin and contains pores, and covered by diaphragm * integrated basal lamina. * tight junction * distributed in mucosa of digestive tract, glomerulus in kidney and some endocrine glands
c. Sinusoidal capillary*larger withirregulardiameter.*Fenestrationswithoutdiaphragm*discontinuous ordisappeared basallamina.*larger spacesamong endothelia*macrophages* distributed inliver.and inhematopoietic
* larger with irregular diameter. * Fenestrations without diaphragm c. Sinusoidal capillary: * discontinuous or disappeared basal lamina. * larger spaces among endothelia * macrophages * distributed in liver,and in hematopoietic
PericyteRedbloodcell in lumenIntercellularcleftEndothelialcellBasementPericytemembranePinocytoticvesiclesPinocytoticTight junctionvesiclesRedblood(a)EndothelialcellinlumennucleusFenestrations(pores)EndothelialIntercellularcleftnucleusEndothelialcellBasementmembraneTight junction(b)PericyteEndothelialcellRedbloodcell in lumenLargeintercellularcleftTight junctionNucleusofIncompletebasementendothelial cellmembrane(c)Copyright 2004Pearson Education, Inc.,publishing as Benjamin Cummings
TLERRBlood-Brain Barrier(BBB)tECaplllarrFeaiTON
Blood-Brain Barrier (BBB)
(3)Function:Selected permeability and exchange of materialSynthesis(VEGFs),conversion(angiotensin I→angiotensin Il) and lipolysisactivityAnti-bloodcoagulate
(3) Function: • Selected permeability and exchange of material • Synthesis (VEGFs), conversion (angiotensin I→angiotensin II) and lipolysis activity • Anti-blood coagulate