第北章病奏
第六节病毒与宿主的相互作用
第六节 病毒与宿主的相互作用
学习目标 一、噬菌体感染对原核细胞的影响 二、病毒感染对真核细胞的影响 三、病毒感染机体的影响因素
学习目标 一、噬菌体感染对原核细胞的影响 二、病毒感染对真核细胞的影响 三、病毒感染机体的影响因素
一、噬菌体感染对原核细胞的影响 E.coli outer membrane Virus DNA
一、噬菌体感染对原核细胞的影响
1.抑制宿主细胞大分子合成 Tail,collar, Nucleases base plate, DNA polymerase Phage head and tail fiber New sigma factors Phage DNA proteins proteins Infection Phage DNA replication Early mRNA Middle mRNA Late mRNA Early proteins Middle proteins Late proteins 10 15 20 Minutes Figure 8.23 Time course of events in phage T4 infection.Following injection of DNA,early and middle mRNA is produced that codes for nucleases,DNA polymerase,new phage- specific sigma factors,and various other proteins involved in DNA replication.Late mRNA codes for structural proteins of the phage virion and for T4 lysozyme,needed to lyse the cell and release new phage particles
1. 抑制宿主细胞大分子合成