Thomas Hunt Morgan Working with Drosophila, established that gene are carried on chromosome and form the functional basis of heredity: essentially establishing the modern science of genetics X X 1866-1945: American Geneticist Professor Columbia and california Institute of Technology; Tan Jiazhen Nobel Prize: Physiology or Medicine 1933 Link with (谈家桢) Fudan “ Father of modern University genetics in China 1909-2008
Thomas Hunt Morgan Link with Fudan University: 1866- 1945; American Geneticist Professor Columbia and California Institute of Technology; Nobel Prize: Physiology or Medicine 1933 Working with Drosophila, established that gene are carried on chromosome and form the functional basis of heredity: essentially establishing the modern science of genetics Tan Jiazhen (谈家桢) “Father of modern genetics in China” 1909-2008
x为了帮助保护您的隐私, PowerPoint己阻止自动下载此图片 Linus Pauling First to demonstrate of the molecular basis of a genetic disease, sickle cell anemia: essentially establishing the field of molecular genetics Sickle-like appearance of red blood cell isolated from sickle cell anemia patient (left) compared to normal red blood cell (right). 1901-1994: American quantum a) Normal c)Sickle Cell Trait chemist and biochemist Professorat the california Institute of Technology Stanford University Nobel Prizes: Chemistry 1954: Peace 1962: Published: b)Sickle Cell Anemia d)50-50 Mixture of a)and b) Itano l et al, "Sickle Cell Anemia, a Molecular Disease' o Electrophoresis of Co-hemoglobin isolated from Science110,1488-1490,1949 rmal Individual (a)or individuals heterozygous(b)or homozygous(c) for hemoglobin mutation
Linus Pauling First to demonstrate of the molecular basis of a genetic disease, sickle cell anemia: essentially establishing the field of molecular genetics 1901-1994; American quantum chemist and biochemist. Professor at the California Institute of Technology & Stanford University Nobel Prizes: Chemistry 1954; Peace 1962; Published: Itano I et al, “Sickle Cell Anemia, a Molecular Disease” Electrophoresis of CO Science110, 1488-1490, 1949 -hemoglobin isolated from normal Individual (a) or individuals heterozygous (b) or homozygous (c) for hemoglobin mutation. Sickle-like appearance of red blood cell isolated from sickle cell anemia patient (left) compared to normal red blood cell (right)
B. Patterns of inheritance within pedigrees Autosomal dominant Penetrance and expressivity Autosomal recessive Consanguinity and inbreeding Co-dominant Incompletely dominant X-inked dominant X-linked recessive Y-linked
B. Patterns of inheritance within pedigrees Autosomal dominant Penetrance and expressivity Autosomal recessive Consanguinity and inbreeding Co-dominant Incompletely dominant X-linked dominant X-linked recessive Y-linked
or union Probands Female ○ Consanguinity and Number of children of sex indicated Monozygotic twins 口 AFfected pedigrees ① Nonpenetrant camer, y manifest disease 口 ○ Dizygotic twin Twins of unknown zygosity Proband and individuals Deceased individual 人 Adopted into family d Adopted out of family Multiple unions Arrow indicates seeking counseling 岛 dates if available 人人
Probands and pedigrees
Punnett squares Sperm Sperm Genotype combination A-allele a-allele of alleles at a specific locus ggs AA aA A-allele Eggs aa a-allele Sperm Sperm A-allele a-allele Eggs AA aA unaffected A= normal(major) allele A-allele a= mutated(minor)allele ggs aa affected a-allele
Sperm A-allele Sperm a-allele Eggs A-allele AA aA Eggs a-allele Aa aa “Punnett squares” Sperm A-allele Sperm a-allele Eggs A-allele AA aA Eggs a-allele Aa aa A = normal (major) allele a = mutated (minor) allele affected A a Genotype = combination of alleles at a specific locus unaffected