Specific, Adaptive Immunity -Acquired Response Invoked when the inflammatory response and complement systems fails Requires stimulation Response time is in days ajor teatures Diversity many different pathogens recognized Specificity -distinguishes particular molecules Memory -responds faster with subsequent exposure Primary immune response is reaction to first exposure Secondary immune response is reaction to exposure using memory"of first response
Specific, Adaptive Immunity - Acquired Response Invoked when the inflammatory response and complement systems fails - Requires stimulation. - Response time is in days. Major features: • Diversity - many different pathogens recognized • Specificity - distinguishes particular molecules • Memory - responds faster with subsequent exposure Primary immune response is reaction to first exposure. Secondary immune response is reaction to exposure using “memory” of first response
Antibodies antibodies are proteins that bind to antigens antigens-a protein or other molecule that causes antibody production antibody generators antibodies are produced by b cell B-cells- type of lymphocyte matures in the bone marrow circulates in the blood and lymph system encounters an antigen-makes a specific antibody each B-cell produces only one antibody -clonal B-cells are the lymphocytes that mediate the Humoral response(antibody-directed immunity)
Antibodies - antibodies are proteins that bind to antigens - antigens - a protein or other molecule that causes antibody production antibody generators - antibodies are produced by B cell B-cells - type of lymphocyte - matures in the bone marrow - circulates in the blood and lymph system - encounters an antigen - makes a specific antibody - each B-cell produces only one antibody - clonal B- cells are the lymphocytes that mediate the Humoral response (antibody-directed immunity)
Tcell lymphocytes. target and destroy infected body cells develop in the bone marrow differentiate into mature T cells in the Thymus gland T cells move in the circulation and the lymphatic system are responsible for the Cellular Response(cell mediated immunity). Antibody-mediated and cell-mediated immune systems work together
T cell lymphocytes. - target and destroy infected body cells - develop in the bone marrow - differentiate into mature T cells in the Thymus gland - T cells move in the circulation and the lymphatic system - are responsible for the Cellular Response (cellmediated immunity). Antibody-mediated and cell-mediated immune systems work together
Humoral response -Antibody-directed Immunity Three basic steps detect the antigen activate helper t cells make the antibodies
Humoral response -Antibody-directed Immunity Three basic steps - detect the antigen - activate helper T cells - make the antibodies
Antigens activate b cells directly and indirectly HOWEVER -indirect is the major pathway. Antigens Antigen-presenting cell (macrophage) Stimulates Helper T cell Stimulates B cells
Antigens activate B cells directly and indirectly HOWEVER - indirect is the major pathway