Ischemia-reperfusion injury (IRD)
Ischemia-reperfusion injury (IRI)
Introduction 1955. Sewel tied up coronary of dog, loose suddenly ventricular fibrillation Kane tied up left entricular branch of coronar of rat ECG no obvious change relieve deligation arrhythmic
Introduction 1955, Sewel tied up coronary of dog， loose suddenly ventricular fibrillation。 Kane tied up left entricular branch of coronary of rat ECG no obvious change relieve deligation arrhythmic
1972 Flore kidney IRi 1978 Modry lung IRI 1981 Greenberg intestine IRI
1972 Flore kidney IRI 1978 Modry lung IRI 1981 Greenberg intestine IRI
Concept based on ischemia injury of tissue and organs restoration of blood ftow after transient or schemia further reversible or irreversible cell damage ischemia reperfusion injury (IRD
Concept: based on ischemia injury of tissue and organs restoration of blood flow after transient or ischemia further reversible or irreversible cell damage ischemia reperfusion injury（IRI）
pH paradOX ischemia acidosis, disorder of function and metbolism on cell severe ri ph paradox calcium paradox pre-perfuse rat heart with no calcium perfusion for 2min perfuse calcium perfusion, cell release enzyme myofibril over-constract, electron signals abnormal,calcium paradox
pH paradox ischemia acidosis , disorder of function and metbolism on cell severe IRI pH paradox calcium paradox pre-perfuse rat heart with no calcium perfusion for 2min perfuse calcium perfusion, cell release enzyme myofibril over-constract, electron signals abnormal， calcium paradox