Histamine dilates local blood vessels increases capillary permeability Result is redneSs, heat and swelling heat -unfavorable to microorganisms mobilizes white blood cells(monocytes) raises metabolic rate of surrounding cells Complement- chemotaxis agent recruits in wbc to injury site The Inflammatory response starts with release of histamine and other chemicals ends with WbC cleaning up the debris
Histamine - dilates local blood vessels - increases capillary permeability Result is redness, heat and swelling heat - unfavorable to microorganisms - mobilizes white blood cells (monocytes) - raises metabolic rate of surrounding cells Complement - chemotaxsis agent - recruits in WBC to injury site The Inflammatory Response - starts with release of histamine and other chemicals - ends with WBC cleaning up the debris
Tissue injury Release of histamine complement, and other chemicals Histamine Histamine Complement Local dilation of Increased local Chemotactic attraction blood vessels capillary permeability of phagocytes to injured area Accumulation of fluid Increased blood delivery to injured area (which includes antibodies omplement, clotting proteins, and phagocytes)in tissue spaces Redness一 Swelling s 相e ain Healing
Complement system chemical defense system that kills microorganisms named the complement system because of the way it works together with the immune system are a series of proteins, cl, C2, etc C5-C9-form a large multi-protein complex MAC-membrane-attack complex MAC-inserts itself into the membrane of invading microorganisms creates a pore disrupts control of ion balance cells burst
Complement System - chemical defense system that kills microorganisms - named the complement system because of the way it works together with the immune system - are a series of proteins, C1, C2 , etc - C5-C9 - form a large multi-protein complex - MAC - membrane-attack complex MAC - inserts itself into the membrane of invading microorganisms - creates a pore - disrupts control of ion balance - cells burst
Complement Bacteria Phagocyte Bacteria ① Ruptures② Establishes③ Coating of (lyses) chemical bacterial cells bacterial cells gradient for enhances attraction of recognition phagocytes and engulfing y phagocytes
Anti-microbial chemicals on the non-specific response collectins recognize the sugar moieties present on the surface of foreign cells cytokines interferons(chemical scouts), alert other cells to the presence of invaders also anti-viral interleukins(fever high temp-kills some infecting bacteria lowers blood iron levels tumor necrosis factor
Anti-microbial chemicals on the non-specific response - collectins - recognize the sugar moieties present on the surface of foreign cells - cytokines - interferons (chemical scouts), alert other cells to the presence of invaders - also anti-viral - interleukins (fever) - high temp - kills some infecting bacteria - lowers blood iron levels - tumor necrosis factor