White blood cells Leucocytes (白细胞)
White blood cells (Leucocytes) （白细胞）
Platelets( Thrombocytes血小板 Platelets are small, granulated bodies that aggregate at sites of vascular injury they lack nuclei and are 24 um in diameter There are about 300,000/ul of circulating blood and they normally have a half-life of about 4 days The megakaryocytes, giant cells in the bone marrow, form platelets by pinching off bits of cytoplasm and extruding them into the circulation Between 60 and 75% of the platelets that have been extruded from the bone marrow are in the circulating blood and the remainder are mostly in the spleen Splenectomy causes an increase in the platelet coun 〔 thrombocytosis
Platelets (Thrombocytes) 血小板 Platelets are small, granulated bodies that aggregate at sites of vascular injury They lack nuclei and are 2–4 μm in diameter There are about 300,000/μL of circulating blood, and they normally have a half-life of about 4 days The megakaryocytes, giant cells in the bone marrow, form platelets by pinching off bits of cytoplasm and extruding them into the circulation Between 60 and 75% of the platelets that have been extruded from the bone marrow are in the circulating blood, and the remainder are mostly in the spleen Splenectomy causes an increase in the platelet count (thrombocytosis)
Physiological properties of platelets Adhesion(粘附 GP‖b/a w WF ● Fibrinogen Fibrin Procoagulant P-sel 分 Activity +GP Ib/X/V Prothrombinase GP|a∥la Complex Adhesion ADP PF4,BTG Aggregation Serotonin Activation And release F DOOUcOOOFib Collagen Subendothelial matrix Prote ins
Physiological properties of platelets Adhesion（粘附）
Physiological properties of platelets Aggregation(聚集) VESSEL INJURY HAEMOSTASIS Tethering Thrombus Translocation Stable Formation Aggregation Adhesion Spreading Exposed proteins at injured site
Physiological properties of platelets Aggregation（聚集）
Physiological properties of platelets Release or secretion(释放或分淤 Dense granule 沙 Canalicula VWF PDGF system fibrinogen TSP 阝TG PF4 factor v ADP GPIIb/IIIa r GPllb/illa ATP GPIb/IX/V VWE GPIa/lIa Area of denuded endothelium vascula endothelial
Physiological properties of platelets Release or secretion（释放或分泌）