从脑到行为,第二章神经系统功能活动的基本原理 钠钾泵 Extracellular Sodium-potassium pumps fluid Na+ K中 Na+ Na+ K+ Nat K+ Na+ ADP Membrane Cytosol Three Na+ions are pumped out of the neuron for every two K+ions that are pumped in 6 Istian@sjtu.edu.cn
从脑到行为,第二章 神经系统功能活动的基本原理 lstian@sjtu.edu.cn 6 Three Na + ions are pumped out of the neuron for every two K+ ions that are pumped in 钠钾泵
局麻剂如何发生作用? 本原理 30 Rising phase 55 -70- 24 2 Time (msec) +30 Repolarization Closed 55- -70- 2 Time (msec) +30 0 Hyperpolarization 55 -70- Istian Time (msec) 7
从脑到行为,第二章 神经系统功能活动的基本原理 lstian@sjtu.edu.cn 7 局麻剂如何发生作用?
从脑到行为,第二章神经系统功能活动的基本原理 动作电位的传导方式 Axon hillock Action potential Axon hillock ++++ + + ××× xxxxx Action potential 8 Istian@sjtu.edu.cn
从脑到行为,第二章 神经系统功能活动的基本原理 lstian@sjtu.edu.cn 8 动作电位的传导方式
从脑到行为,第二章神经系统功能活动的基本原理 动作电位的跳跃式传导 Node of Main symptoms of nternode Myelin Multiple sclerosis Ranvier Central: -Fatique Visual:- -Cognitive -Nystagmus B impairment -Optic neuritis .Depression Diplopia Unstable mood Speech: Dysarthria Throat: Dysphagia Musculoskeletal: Demyelinated region .Weakness .Spasms .Ataxia 多发性硬化症:慢性脱髓鞘疾病 Sensation: .Pain Hypoesthesias Paraesthesias 格林-巴利综合征:急性脱髓鞘疾病 Bowel:- -Incontinence -Diarrhea or constipation Urinary Incontinence Frequency or 9 Istian@sjtu.edu.cnto
从脑到行为,第二章 神经系统功能活动的基本原理 lstian@sjtu.edu.cn 9 多发性硬化症:慢性脱髓鞘疾病 格林-巴利综合征: 急性脱髓鞘疾病 动作电位的跳跃式传导