第四章 微生物的合成代谢
第四章 微生物的合成代谢
Principles Governing Biosynthesis macromolecules are synthesized from limited number of simple structural units (monomers) -saves genetic storage capacity,biosynthetic raw material,and energy many enzymes used for both catabolic and anabolic processes saves materials and energy
Principles Governing Biosynthesis • macromolecules are synthesized from limited number of simple structural units (monomers ) – saves genetic storage capacity, biosynthetic raw material, and energy • many enzymes used for both catabolic and anabolic processes – saves materials and energy
More principles. ·catabolic and Anabolic anabolic pathways Amphibolic are not identical. despite sharing many enzymes - permits 0 independent E regulation 日 A
More principles. • catabolic and anabolic pathways are not identical, despite sharing many enzymes – permits independent regulation
More principles. ● to synthesize molecules efficiently,anabolic pathways must operate irreversibly in the direction of biosynthesis done by coupling breakdown of ATP to certain reactions in biosynthetic pathways - drives the biosynthetic reaction to completion in eucaryotes,anabolic and catabolic reactions located in separate compartments allows pathways to operate simultaneously but independently
More principles. • to synthesize molecules efficiently, anabolic pathways must operate irreversibly in the direction of biosynthesis – done by coupling breakdown of ATP to certain reactions in biosynthetic pathways – drives the biosynthetic reaction to completion • in eucaryotes, anabolic and catabolic reactions located in separate compartments – allows pathways to operate simultaneously but independently
More principles. catabolic and anabolic pathways use different cofactors catabolism produces NADH -NADPH used as electron donor for anabolism large assemblies (e.g.,ribosomes)form spontaneously from macromolecules by self-assembly
More principles. • catabolic and anabolic pathways use different cofactors – catabolism produces NADH – NADPH used as electron donor for anabolism • large assemblies (e.g., ribosomes) form spontaneously from macromolecules by self-assembly