T细胞活化涉及到的分子 抗原识别:双识别:TCR-肽, TCR-MHC 共受体:CDA-MHCI1CD8MHCI Th细胞活化的“双信号模型” Signal 1: TCR+MHCI-peptide Signal 2: cD28+B7 CD2+LFA3 LFAI+ICAM-1
➢抗原识别：双识别:TCR-肽，TCR-MHC 共受体:CD4-MHCII, CD8-MHCI Th细胞活化的“双信号模型”; Signal 1: TCR+MHCII-peptide Signal 2: CD28+B7 CD2+LFA3 LFA1+ICAM-1 一、T细胞活化涉及到的分子
APC与Th间相互作用的分子 Molecules between apc and th cell interaction TH cell Antigen presenting cell Peptide CD2 do k..-3 LFAl“O IAMI TCR- CLass ll CD3 MHC woo CDx CD45R -woody CD22 CD28 WE
APC与Th间相互作用的分子 Molecules between APC and Th cell interaction
Th细胞活化的“双信号模型” Two-Signal model for th cell activation Co-stimulation of T helper cells by professional APC SIGNAL 2 Cognate T-professional APC co-stimu latory interaction CD28B7.1 Danger APC Processing IFN lL-1.lL-12 SIGNAL 1 Antigen re cogn ition co-receptor ligation induces CD28 on t cells Signal 1 signal 2 are required for t cell clonal proliferation and di ffere ntiation to effe ctor cells
Th细胞活化的“双信号模型” Two-Signal Model for Th Cell Activation
Th细胞活化的“双信号模型” Two-Signal Model for Th Cell activation Mechanism of co-stimulation in T cells High affin it IL-2 Re ceptor- Low affinity aβ and y chains IL-2 Re ceptor- β and y chains 2 IL-2 IL-2 IL-2 △ IL-2Rc N IL-2Rc IL-2Ro Re sting T cell Signal 1 Signal 2 Induction of Increases IL-2 transcription high affinit and stabilises IL-2 mRNA IL-2R
Th细胞活化的“双信号模型” Two-Signal Model for Th Cell Activation