(2)基本理论血栓止血理论的适用Unstable Plaque范围Thin, vulnerablecap小血管和微血管大血管与粥样硬化的问题Unstableplaque has a thin血液流变学问题calcifiedcapcoveringalargerfttycoreUnstableplaqueis morelikelytoRupturerupture, which can triggeaheartattackorstroke.@2004-Duplicationot permikted
基本理论（2） ◼ 血栓止血理论的适用 范围 小血管和微血管 ◼ 大血管与粥样硬化的 问题 ◼ 血液流变学问题
Simple Squamous EpitheliumintheCapillarvWallFenestrations-"windows"Basal laminawhichincreasetransportincertain capillaries-Nucleus ofendothelial cellRed blood cellLumen ofcapillaryTight junctionsA capillaryis composed ofsimple squamous cells whichIntercellularcleftsroll to produce a tube.Capillaries are made only of endothelium
Capillaries are made only of endothelium
微动脉真毛细血管毛细血管前括约肌中间微动脉V动静脉短路微静脉
基本理论（3）■参与血栓的因素有形成分：血小板、红细胞、中性粒细胞、单核细胞、淋巴细胞、内皮细胞无形成分：凝血因子（蛋白）、血液凝固调节蛋白、细胞因子（炎性因子，趋化因子，黏附分子等）血流
基本理论（3） ◼ 参与血栓的因素 有形成分：血小板、红细胞、中性粒细 胞、单核细胞、淋巴细胞、内皮细胞 无形成分：凝血因子（蛋白）、血液 凝固调节蛋白、细胞因子（炎性因子， 趋化因子，黏附分子等） 血流
The Role of Activated Protein CinSevereSepsisCOAGULATIONCASCADETissueFactorActivatoProteinCEndotheliumFactor VillaIL-6FactorVaInactivationIL-1TNF-αLTHROMBINInactivationoCinnrneendFibrinTAFIFibrindTissueFactorReductionofRollingThromboticResponseFibrinolytic ResponseInflammatoryResponseto InfectiontoInfectionto Infection
Endothelium Neutrophil Monocyte IL-6 IL-1 TNF- IL-6 Activated Protein C Inactivation Inactivation Inactivation Prevention of activation Activated Protein C Inflammatory Response to Infection Thrombotic Response to Infection Fibrinolytic Response to Infection TAFI PAI-1 Suppressed fibrinolysis Activated Inhibition Protein C Inhibition Activated Protein C Factor VIIIa Tissue Factor COAGULATION CASCADE Factor Va THROMBIN Fibrin Fibrin clot Tissue Factor Organisms The Role of Activated Protein C in Severe Sepsis