think of the past eight years of my life in New York at Rockefeller University as a personal odyssey The new laboratory started out very small, with only Declan, Alice and me. But it grew in the first year with the addition of other enthusiastic postdoctoral scientists, including Joao Morais cabra and John Imredy. Working with membrane proteins was very difficult as expected. We had our periods of despair, but every time we felt left without options something good happened and despair gave way to excitement. Persistence and dedication eventually paid off. The atomic structure of the K+ selectivity filter was more informative and more beautiful than I ever could have imagined My laboratory now is an incredible place, overflowing with excitement and ideas sustained by the continual infusion of bright young scientists who come from around the world to work with me. It gives me great satisfaction to know that these young scientists who are sophisticated in their knowledge of protein chemistry and structure will lead the field of ion channel research into the future. This has been a wonderful adventure. I owe thanks for the life I have: to Alice, to all my loving family of MacKinnons and Lees, to my scientific family of students, postdocs and colleagues to senior colleagues who have helped me along my way to pursue my passion, and to the Rockefeller University, the Howard Hughes Medical Institute, and the National Institutes of Health for their support. I am very thankful for my life as a scientist, for the opportunity to understand in some small way the world around me. I hope my best experiment and scientific ideas are yet to come. This hope keeps me going http://ww.nobelprize.org/nobel_prizes/chemistr Laureates/2003/mackinnon html
I think of the past eight years of my life in New York at Rockefeller University as a personal odyssey. The new laboratory started out very small, with only Declan, Alice and me. But it grew in the first year with the addition of other enthusiastic postdoctoral scientists, including João Morais Cabral and John Imredy. Working with membrane proteins was very difficult as expected. We had our periods of despair, but every time we felt left without options something good happened and despair gave way to excitement. Persistence and dedication eventually paid off. The atomic structure of the K+ selectivity filter was more informative and more beautiful than I ever could have imagined. My laboratory now is an incredible place, overflowing with excitement and ideas sustained by the continual infusion of bright young scientists who come from around the world to work with me. It gives me great satisfaction to know that these young scientists who are sophisticated in their knowledge of protein chemistry and structure will lead the field of ion channel research into the future. This has been a wonderful adventure. I owe thanks for the life I have: to Alice, to all my loving family of MacKinnons and Lees, to my scientific family of students, postdocs and colleagues, to senior colleagues who have helped me along my way to pursue my passion, and to the Rockefeller University, the Howard Hughes Medical Institute, and the National Institutes of Health for their support. I am very thankful for my life as a scientist, for the opportunity to understand in some small way the world around me. I hope my best experiment and scientific ideas are yet to come. This hope keeps me going. http://www.nobelprize.org/nobel_prizes/chemistry /laureates/2003/mackinnon.html
NooN General properties cryptand-222 1. Valence electron of alkali metals (1)其氧化数为+1,不会有其它正氧化态。 在无水无氧条件下,可以制得低氧化态的非 寻常化合物。例如钠在乙二胺和甲胺中所形 成的溶液也具有导电性,观察到Na的光谱 带,说明主要的导电体应是钠电离出的Na 和Naˉ。 2Na- en+]NH2> Na++Na 2Na(s)+ C20H3606 [Na( C20H3606)]. Na
一、General properties 1. Valence electron of alkali metals: (1)其氧化数为+1，不会有其它正氧化态。 在无水无氧条件下，可以制得低氧化态的非 寻常化合物。例如钠在乙二胺和甲胺中所形 成的溶液也具有导电性，观察到Na-的光谱 带，说明主要的导电体应是钠电离出的Na+ 和Na- 。 + + − 2Na ⎯⎯⎯⎯⎯→ Na + Na C H3 NH2 en 2Na(s) + C20H36O6 [Na(C20H36O6)]+ ·Na－ cryptand-222
H HO-CH,coo 3Na一 N Nao-CH?CooNa↓ Na+12H 2 Inverse sodium hydride
Inverse sodium hydride + ½ H2
(2)由于价电子数少,所以碱金属原 子之间的作用力比绝大多数其他金属 原子之间的作用力要小,因此碱金属 很软,低熔沸点,且半径大、密度小。 L的密度是所有金属中最小的,它的 密度比煤油小
(2) 由于价电子数少，所以碱金属原 子之间的作用力比绝大多数其他金属 原子之间的作用力要小，因此碱金属 很软，低熔沸点，且半径大、密度小。 Li的密度是所有金属中最小的，它的 密度比煤油小
2.在形成化合物时,碱金属元素以离子键 结合为特征,但也呈现一定程度的共价性。 (1)气态双原子分子Na、Cs2以共价键结合 (2)凵的一些化合物共价成份最大,从Li cs的化合物,共价倾向减小
2. 在形成化合物时，碱金属元素以离子键 结合为特征，但也呈现一定程度的共价性。 (1) 气态双原子分子Na2 、Cs2以共价键结合 (2) Li的一些化合物共价成份最大，从Li Cs的化合物，共价倾向减小