Good Research Is the Key o My English is not good o They are biased against Chinese(foreigners) 人家没做过你就要做 0这是新的卡这是好的
Good Research Is the Key My English is not good They are biased against Chinese (foreigners) 人家没做过= 你就要做 这是新的 = 这是好的
What Is a First-Class Paper/Research? o Major advance in a classic field 干细胞是如何分化成特定组织细胞的,胆固醇在人体的正常功用 D New techniques and methods that can be widely used 人类基因组研究中的自动测序技术,PCR, Patch clamp,Ca2+ Imaging, gfp o Discoveries with obvious practicalimplications AIDS virus receptor的发现,老年痴呆症基因的发现 o Conceptual breakthrough, novelideas 神经营养因子可以促进学习记忆,RNA干扰现象 o Challenge to traditional views, break dogma 脑内有可分裂的神经干细胞,打破了传统观念 D Opening up new area, cross board “细胞凋亡”现象的发现,开辟了新的科研领域
What Is a First-Class Paper/Research? Major advance in a classic field 干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用 New techniques and methods that can be widely used 人类基因组研究中的自动测序技术, PCR, Patch clamp, Ca2+ Imaging, GFP Discoveries with obvious practical implications AIDS virus receptor 的发现, 老年痴呆症基因的发现 Conceptual breakthrough, novel ideas 神经营养因子可以促进学习记忆, RNA干扰现象 Challenge to traditional views, break dogma 脑内有可分裂的神经干细胞，打破了传统观念 Opening up new area, cross board “细胞凋亡”现象的发现, 开辟了新的科研领域
What Is a Mediocre Paper/Research? Horizontal growth I made the discovery in rats, you find the same in cat. Filling gaps EGF activates JNK which is known to induce c-Jun expression You show that EFG enhances c-Jun expression. Working out details I found NO induces the production of cGMP, you work out dose response and time course Support existing idea, "me too EGF-R endocytosis requires dynamin, PDGF-R too Follow up CREB binds to CRE. Working out CRE sequence Incomplete study, preliminary
What Is a Mediocre Paper/Research? • Horizontal growth I made the discovery in rats, you find the same in cat. • Filling gaps EGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. • Working out details I found NO induces the production of cGMP, you work out dose response and time course. • Support existing idea, “me too” EGF-R endocytosis requires dynamin, PDGF-R too. • Follow up CREB binds to CRE. Working out CRE sequence. • Incomplete study, preliminary
How to Read Scientific Papers? The Gilbert way Keep these in mind when you read What is the major question addressed in this paper? Is this question important and why? What are the approaches used in this paper, and whether they are adequate for the questions? What is the concept coming out of this pa per? proaches? What are the novel idea or using innovative ap Do the results presented support this new concept? Weekly reading of CNS titles Critical, appreciative
How to Read Scientific Papers? • The Gilbert way • Keep these in mind when you read • What is the major question addressed in this paper? • Is this question important and why? • What are the approaches used in this paper, and whether they are adequate for the questions? • What are the novel idea or using innovative approaches? • What is the concept coming out of this paper? • Do the results presented support this new concept? • Weekly reading of CNS titles • Critical, appreciative
What makes Good Science? Important and significant Original and innovative Solid and rigorous Unique and unusual Novelty is essential 语不惊人誓不休
What Makes Good Science? • Important and significant • Original and innovative • Solid and rigorous • Unique and unusual Novelty is essential 语不惊人誓不休