1920年发现BCG( Bacillus calmette-Guerin) Calmette guerin (1906-1921) M. bovis: low toxicity 1921 first iniection 1930 a disaster slowed public acceptance of the vaccine ■1945 worldwide used The most popular vaccine BcG:牛型结核杆菌(有毒株) 胆汁甘油-马铃薯培养 13年,230次传代 减毒株(BcG) 5/3/2016 Mycobacteria s lecture for MD students
5/3/2016 Mycobacteria-Junqi's Lecture for MD students 11 Calmette & Guérin (1906-1921) M. bovis; low toxicity 1921 first injection 1930 a disaster slowed public acceptance of the vaccine 1945 worldwide used The most popular vaccine 1920年发现BCG (Bacillus Calmette-Guérin ) BCG：牛型结核杆菌（有毒株） 胆汁-甘油-马铃薯培养 13年，230次传代 减毒株（BCG）
抗结核药物的问世 令In1943 Streptomycin(链霉素) was first isolated on october19, by Albert schatz, a graduate student, in the laboratory of Selman abraham Waksman at Rutgers University, and was the first antibiotic remedy for tuberculosis 令in1951, Isoniazid(异烟肼,INH) was found to be effective against tuberculosis by inhibiting its mycolic acid(wax coat) 令 Rifampicin(利福平,INN) was produced in1959, and was introduced in 1967as a major addition to the cocktail-drug treatment of tuberculosis 消灭结核病? 5/3/2016 Mycobacteria- Jungi's Lecture for 12 MD students
5/3/2016 Mycobacteria-Junqi's Lecture for MD students 12 In 1943 Streptomycin(链霉素) was first isolated on October 19, by Albert Schatz, a graduate student, in the laboratory of Selman Abraham Waksman at Rutgers University, and was the first antibiotic remedy for tuberculosis in 1951, Isoniazid (异烟肼， INH) was found to be effective against tuberculosis by inhibiting its mycolic acid (wax coat) Rifampicin（利福平，INN）was produced in 1959，and was introduced in 1967as a major addition to the cocktail-drug treatment of tuberculosis 抗结核药物的问世 消灭结核病？
结核病的死灰复燃 .In 1995, a total of 3 million people were died of tuberculosis worldwide sIn 1996, the World Health Organization (WHO and International Union Against Tuberculosis and Lung diseases qUaTLD) claimed that march 24 be an official World Tuberculosis Day. In 1997. who and uatld endorse a comprehensive strategy Directly-Observed Treatment Short-course DOTS) to detect and cure TB patients. 5/3/2016 Mycobacteria- Jungi's Lecture for 13 MD students
5/3/2016 Mycobacteria-Junqi's Lecture for MD students 13 In 1995, a total of 3 million people were died of tuberculosis worldwide In 1996, the World Health Organization (WHO) and International Union Against Tuberculosis and Lung Diseases (IUATLD) claimed that March 24 be an official World Tuberculosis Day. In 1997, WHO and IUATLD endorse a comprehensive strategy Directly-Observed Treatment Short-course (DOTS) to detect and cure TB patients. 结核病的死灰复燃
Global TB Epidemics -WHO Estimation THE writen d the poce of o mysery thriven roby occurce in certific detail 17th-18th century 1 /5 of adults was killed ° ORGOTTEN ■1850-1950 PLAGUE I billion people killed HoW THE BATTLE ■2000-2009 AGAINST TUBERCULOSIS 300M new infection WAS WON AND LOST 90M New cases FRANK RYAN, MD 30M Deaths 5/3/2016 Mycobacteria- Jungi's Lecture for 14 MD students
5/3/2016 Mycobacteria-Junqi's Lecture for MD students 14 Global TB Epidemics 17th -18th century 1/5 of adults was killed 1850-1950 1 billion people killed 2000-2009 －300M new infection －90M New Cases －30M Deaths -WHO Estimation
“7 B claims1.7 million Yes, We Can lives each year, and eliminating it Will be a global challenge-but it's a challenge we must take on Barack obama ct.3.2008 神国比【有 5/3/2016 Mycobacteria-Junqi's Lecture for 15 MD students
5/3/2016 Mycobacteria -Junqi's Lecture for MD students 15