上游文通大学 antipsychotic drugs Shanghai Jiao Tong University Schizophrenia(精神分裂症)：mental disorder characterized by a disintegration of thought processes and of emotional responsiveness etiology: genetic cause +eg,influenza during pregnancy;hypoxia at birth +social /or psychological causes =unstable function of the brain and/or deficiency of brain structure
Shanghai Jiao Tong University antipsychotic drugs Schizophrenia(精神分裂症）： mental disorder characterized by a disintegration of thought processes and of emotional responsiveness etiology: genetic cause ＋eg, influenza during pregnancy; hypoxia at birth ＋social /or psychological causes ＝unstable function of the brain and/or deficiency of brain structure
上克通大睾 Etiology Shanghai Jiao Tong University homozygous twin,40%~50% parent-offspring:10%; common population:1%worldwide 80%genetic trend (gene therapy?) many genes cloned:RGS4,DISC1, dysbindin,neuregulin,G72,CHRNA7, COMT,PRODH,..(贺林院士较多贡献) gene+environment/psychological factors
Shanghai Jiao Tong University Etiology homozygous twin，40％～50％ parent-offspring：10％; common population：1％worldwide 80％genetic trend (gene therapy?) many genes cloned：RGS4, DISC1, dysbindin, neuregulin, G72, CHRNA7, COMT, PRODH, …（贺林院士较多贡献） gene＋environment/psychological factors
上充通大￥ Clinical manifestations Shanghai Jiao Tong University > delusion(妄想)：greatness,lovingness, delusion of being killed, > illusion(幻觉)：auditory hallucination > disordered thought: 医生：你好吗？ 病人：我不是坏人。 病人：（见医生着红毛衣)红色代表革命，白色 代表反革命。所以我不吃白米饭，要吃的话，我吃红 米饭。 >disordered emotion:对外界各种刺激的心理反应 不合逻辑 >bizarre（怪诞)：乱吃、不修边幅、无意识动作
Shanghai Jiao Tong University Ø delusion(妄想)：greatness, lovingness, delusion of being killed, … Ø illusion(幻觉)：auditory hallucination Ø disordered thought： 医生：你好吗？ 病人：我不是坏人。 病人：（见医生着红毛衣）红色代表革命，白色 代表反革命。所以我不吃白米饭，要吃的话，我吃红 米饭。 Ø disordered emotion:对外界各种刺激的心理反应 不合逻辑 Ø bizarre（怪诞） ：乱吃、不修边幅、无意识动作 Clinical manifestations
上游充通大￥ Shanghai Jiao Tong University Ideal anti-psychotic drugs 后 Should be: affecting psychological activity firstly no significant deep sleep and anesthesia with larger dose no significant anti-convulsive activity
Shanghai Jiao Tong University Ideal anti-psychotic drugs Should be: affecting psychological activity firstly no significant deep sleep and anesthesia with larger dose no significant anti-convulsive activity
上浒克通大睾 Therapeutic history Shanghai Jiao Tong University before 1800's,locked by iron chain 1933,insulin shock 1934,pentetrazole (戊四唑)-induced convulsion 1937.electroconvulsive treatment electrodes on temporals,100-140 volt, 0.3-0.6 s,transient loss of consciousness and general convulsion 1950，chlorpromazine (氯丙嗪)
Shanghai Jiao Tong University l before 1800’s, locked by iron chain l 1933, insulin shock l 1934, pentetrazole（戊四唑）-induced convulsion l 1937, electroconvulsive treatment electrodes on temporals， 100－140 volt， 0.3-0.6 s，transient loss of consciousness and general convulsion l 1950, chlorpromazine （氯丙嗪） Therapeutic history