Toxicity, Sedative Hypnotics 中山急诊姚晨玲
Toxicity, SedativeHypnotics 中山急诊 姚晨玲
Background Sedative-hypnotics are a group of drugs that cause CnS depression Benzodiazepines(bzd) the most commonly a barbiturates used agents a nonbarbiturate nonbenzodiazepine sedative hypnotics( nbnb
Background Sedative-hypnotics are a group of drugs that cause CNS depression. ◼ Benzodiazepines (BZD) ◼ barbiturates ◼ nonbarbiturate nonbenzodiazepine sedativehypnotics (NBNB) the most commonly used agents
Background acute sedative-hypnotics poisoning a withdrawal syndrome
Background ◼ acute sedative-hypnotics poisoning ◼ withdrawal syndrome
Etiology Benzodiazepines(BzD) Long acting(half life >30h) chlordiazepoxide(利眠宁) diazepam(地西泮、安定) flurazepam(氟安定) Short acting(half life 6-30h) alprazolam(阿普唑仑) Ultrashort acting triazolam(三唑仑)
Etiology Benzodiazepines (BZD) • Long acting (half life >30h): chlordiazepoxide (利眠宁) diazepam（地西泮、安定） flurazepam （氟安定） • Short acting (half life 6-30h): alprazolam(阿普唑仑) • Ultrashort acting : triazolam(三唑仑)
Etiology Barbiturates Ultrashort acting Methohexital Brevital甲己炔巴比妥) thiopental( Pentothal硫喷妥那) Short acting pentobarbital( Nembutal巴比妥) secobarbital( Seconal司可巴比妥 Intermediate acting Amobarbital( Amytal异戊巴比妥) butalbital( Fioricet, Fiorina|异丁巴比妥) ong acting Phenobarbital( Luminal鲁米那)
Etiology ◼ Barbiturates ◼ Ultrashort acting ◼ Methohexital (Brevital甲己炔巴比妥) ◼ thiopental (Pentothal硫喷妥那) ◼ Short acting ◼ pentobarbital (Nembutal戊巴比妥) ◼ secobarbital (Seconal司可巴比妥) ◼ Intermediate acting ◼ Amobarbital (Amytal异戊巴比妥) ◼ butalbital (Fioricet, Fiorinal异丁巴比妥) ◼ Long acting ◼ Phenobarbital (Luminal鲁米那)