NiCl/CrCl2 Coupling Cont OHC oc(O)t-Bu oc(O)t-Bu CrCl(excess NCl2(0.5%) H t-BuPh2 siOn t-BuPh sio Me DMSO/Me2S (73%) Me OHC、 e HO Me (+)-ophiobolin C Rowley, M., Tsukamoto, M. Kishi, Y; ,J. Am. Chem. Soc. 1989, 111, 2735
NiCl2/CrCl2 Coupling Cont. Coupling Cont. O t-BuPh2SiO I H Me OC(O)t-Bu Me H H CrCl2 (excess) NiCl2 (0.5%) DMSO/Me2S (73%) OHC O t-BuPh2SiO H HO Me H OC(O)t-Bu Me H H H Me H Me H H Me Me O HO Me OHC H (+)- ophiobolin C Rowley, M.; Tsukamoto, M.; Kishi, Y.; J. Am. Chem. Soc. 1989, 111, 2735
Notable reactions NiCl/CrCl2-catalyzed coupling reaction between vinyl iodides and aldehydes Pd(o) catalyzed and thallium hydroxide assisted synthesis of cis-trans conjugated dienes from vinyl iodides and vinyl boronic acids a New methods for the construction of N-acyl vinylogous ureas
Notable Reactions Notable Reactions NiCl 2/CrCl 2 -catalyzed coupling reaction catalyzed coupling reaction between vinyl iodides and aldehydes between vinyl iodides and aldehydes Pd(0) catalyzed and thallium hydroxide assisted Pd(0) catalyzed and thallium hydroxide assisted synthesis of synthesis of cis -trans conjugated dienes from conjugated dienes from vinyl iodides and vinyl boronic acids. vinyl iodides and vinyl boronic acids. New methods for the construction of N New methods for the construction of N -acyl vinylogous ureas vinylogous ureas