3. Balance of body water and sodium drink 1200ml water intake food 1000ml (2000-2500ml) oxidation 300ml balance of water urine 1200-1500ml water loss skin 500ml (2000-2500ml) respiration 350ml eces 150ml Balance r Intake/d 100-200mmol (digestive tract) of sodium Loss/d 100-200mmol (urinary system) ECF:50‰ Distribution ICF: 10% of sodium(骨基质:40%(正常血清钠:130-150mmo
3. Balance of body water and sodium drink 1200ml water intake food 1000ml (2000-2500ml) oxidation 300ml balance of water urine 1200-1500ml water loss skin 500ml (2000-2500ml) respiration 350ml feces 150ml Balance Intake/d 100-200mmol (digestive tract) of sodium Loss/d 100-200mmol (urinary system) ECF:50% Distribution ICF: 10% of sodium 骨基质:40% (正常血清钠:130-150mmol)
C Regulation of osmotic pressure and volume Hypertonic thirst of ECF l. body water↓ ADHt; aldosterone↓ sodium↑ thirst AngⅡtADH body volume↓ aldosterone↑ receptor of volume e ADH 2. body water f sodium↓」ADH reabsorption of sodium I 3 blood volume f→+ANP1 aldosterone(ADS)↓ tension 4. others ADH↑ pa an
(三) Regulation of osmotic pressure and volume Hypertonic thirst of ECF 1.body water ADH ; aldosterone sodium thirst Ang Ⅱ ADH body volume aldosterone receptor of volume ADH 2.body water sodium ADH reabsorption of sodium 3.blood volume ANP aldosterone(ADS) tension 4.others ADH pain
Figure: regulation ofadh secretion osmotic pressure R pressure R ADH volume r heart
Figure: regulation of ADH secretion osmotic pressure R pressure R ADH volume R heart
二、 water and sodium disorders hypertonic ypertonIc dehydration isotonic water excess 3 isotonic hypotonic hypotonic ()细胞外液容量不足( extracellular fluid deficit) 1. Hypotonic dehydration sodium loss water loss serum sodium 130mmoVL plasma osmotic pressure 280m0sm/L
二、water and sodium disorders hypertonic hypertonic dehydration isotonic water excess isotonic hypotonic hypotonic (一) 细胞外液容量不足(extracellular fluid deficit) 1. Hypotonic dehydration sodium loss ＞ water loss serum sodium ＜ 130mmol/L plasma osmotic pressure ＜ 280mOsm/L