DNA X Figure Genome of Hepatitis B Virus
Figure . Genome of Hepatitis B Virus
Etiology Hepatitis B virus (HBv 10 10 antigenic subtypes(mainly adw, adr, ayw, ayr) 10 4 antigen-antibody system HBSAg-anti-HBS HBeAg- anti-HBe HBcAg- anti-HBc(g M& Ig g) HBxAg-anti-HBX 10 Partially double-stranded DNA (HBV DNA) 10 Very strong resistance Inactivation needs100℃10or65℃10h
Hepatitis B virus (HBV) 10 antigenic subtypes(mainly adw, adr, ayw, ayr) 4 antigen – antibody system HBsAg – anti-HBs HBeAg – anti-HBe HBcAg – anti-HBc(Ig M & Ig G) HBxAg – anti-HBx Partially double-stranded DNA (HBV DNA) Very strong resistance Inactivation needs 100℃10’ or 65℃10h Etiology Etiology
HBV 基因型( Genotype) 亚型( Subtype) 准种( Quasispecies 陈佩斯的猫张曼玉的猫崔永元的猫冯巩的猫赵本山的猫周杰伦的猫
Extracellular · Receptor HBV HBe Ag(P18) Intracellular HBsAg(P25, P31, P43) ENDOPLASMIC Endocytosis RETICULUM Fusion 22nm particle @ HBeAg(P22) NUCLEUS GOLGI Nucleocapsid (Co APPARATUS VESICLE RNA 3.5Kb RNA 2. 4kb rNA HBCAg, Pol, HBeAg 2.1kb RNA HBsAg(P43/GP46) 0.7kb RNA BsAg(P25/GP 28, GP33/GP36) BaG HBV is replicate through reverse transcription
Extracellular Intracellular Endocytosis Fusion with NUCLEUS ENDOPLASMIC RETICULUM GOLGI APPARATUS 3.5kb RNA 2.4kb RNA 0.7kb RNA HBcAg,Pol,HBeAg HBsAg (P43/GP46) HBsAg (P25/GP28,GP33/GP36) HBxAg TRANSPORT VESICLE HBV Nucleocapsid DNA RNA HBeAg (P22) HBeAg(P18) HBsAg (P25,P31,P43) 22nm particle plasma membrane Receptor 2.1kb RNA HBV is replicate through reverse transcription
Epidemiology Hepatitis B is a serious public health problem in the world 10 Source of infection acute and chronic patients, or chronic "carriers 10 Rout of transmission Parenteral rout(e. g blood, maternal-infant .) 10 Susceptibility: all anti-HBs( persons 0 Characterizations: epidemic in Asia, Africa and Far East higher risk in early childhood
Source of infection: acute and chronic patients, or chronic “carriers” Rout of transmission: Parenteral rout(e.g blood, maternal-infant…) Susceptibility: all anti-HBs (-) persons Characterizations: epidemic in Asia, Africa and Far East higher risk in early childhood Epidemiology Etiology Hepatitis B is a serious public health problem in the world