Etiology Hepatitis a viruS (HAv 0 One serotype, one antigen-antibody system HAA g Anti-HAV: anti-HAV IgM--marker for acute HAV infection(3-6 m) anti-HAV IgG -indicator of immunity to HAV Strong resistance, alive very long at low temperature 0 Inactivated by heating to 80C5 min or 100oC 1 min ultraviolet light formalin solution
Hepatitis A virus (HAV) One serotype, one antigen-antibody system HAAg Anti-HAV: anti-HAV IgM --- marker for acute HAV infection(3-6 m) anti-HAV IgG --- indicator of immunity to HAV Strong resistance, alive very long at low temperature Inactivated by heating to 80oC 5’ min or 100oC 1’ min ultraviolet light formalin solution Etiology Etiology
Epidemiology Hepatitis a is a highly contagious disease 0 Source of infection: early phase of acute illness or subclinical patients haV in the stool: 1 to 2 weeks before or after the onset of illness Rout of transmission: fecal---oral 0 Susceptibility: all non-Immune people 0 Characterizations: epidemic in the developing countries, peak at Spring highest attack rates in 5-14 year olds
Hepatitis A is a highly contagious disease Source of infection: early phase of acute illness or subclinical patients HAV in the stool: 1 to 2 weeks before or after the onset of illness Rout of transmission: fecal --- oral Susceptibility: all non-immune people Characterizations: epidemic in the developing countries, peak at Spring highest attack rates in 5-14 year olds Epidemiology Etiology
Epidemiology How is Hepatitis A Spread? usually spread by fecal-oral route Close personal contact: sporadic forms (e.g, household contact, child day care centers, sex contact, Contaminated food, water: epidemic or outbreaks (e. g, infected food handlers, raw shellfish) Blood exposure( very rare) (e.g., injecting drug use, transfusion
usually spread by fecal --- oral route ◼ Close personal contact: sporadic forms (e.g., household contact, child day care centers ,sex contact,) ◼ Contaminated food, water: epidemic or outbreaks (e.g., infected food handlers, raw shellfish) ◼ Blood exposure ( very rare) (e.g., injecting drug use, transfusion) How is Hepatitis A Spread? Epidemiology
Etiology Hepatitis B- HBV 1042nm, enveloped spherical particle 8. F00245 (0 Three forms Big spherical Dane particle): 42nm Small spherical: 22nm spherical Filamentary: 22nm/100-1000nm 0 Hepadnaviridae family which include hbv. wh. gshv DHBV
Hepatitis B --- HBV 42nm, enveloped spherical particle Three forms: Big spherical(Dane particle): 42nm Small spherical: 22nm spherical Filamentary: 22nm/100-1000nm Hepadnaviridae family which include HBV, WHV, GSHV, DHBV Etiology Etiology
Dane s particle HBsAg HBcAg …" HBV DNA DNAP
Dane’s particle HBsAg HBcAg HBV DNA DNAP