EscherichiacolilipopolysaccharideGica1-6Glca12Rhaα1-3FucNAc-Core-LipidGIcNAca1Manα166Manα13Manα1-2Manα1-2Manα1.6Mana1-6Mana1-2Mana1Mana1-2ManMana16Candidaalbicansmannan2Manα1Manβ1-2Manα1-2Manα1-2Manα1Manα1-Core-GlcNAcβ1-4GlcNAcβ1-AsnLeishmaniadonovani lipophosphoglycanManα1-2Manα1-P-[6Galβ1-4Manα1-P]-6Gala1-6Galα1-3Galf/β1-3Manα1-3Manα1-4GlcN-Lipid6Glcα1-PManα1-2Manα1-5Araβ1-2Araβ1-(Ara)n-Manα1Mycobacteriumtuberculosislipoarabinomannan62Mana16Mana12Manα1Manar2Manα1Mana12Manα1Mana1Manα1-Core-Lipid
ManOligosaccharideAsn-187Glu-193Glu-185Asn-205Asp-206OONCa2OOc0Four hydrogen bondsMan; Gal; innateimmuneresponseMan and GlcNAc
Four hydrogen bonds Man and GlcNAc Man; Gal; innate immune response
MBP interacts onlywith the terminal sugars,dissociationconstant 1 mM;same asa monosaccharideHigh-affinity binding requires multiple CRD and multipleterminalManGlycansonpathogensurfaceSurface glycansTrimerofC-typeCRDsCRDSarrays ofterminalCollagenα-Helicaltailsnecksugars found on thesurfaces bfmicroorganisms
MBP interacts only with the terminal sugars, dissociation constant 1 mM; same as a monosaccharide High-affinity binding requires multiple CRD and multiple terminal Man arrays of terminal sugars found on the surfaces of microorganisms
Mana16Mana1-3Manα1-2Manα1-2Mana1,6Mana1Mana1-6CandidaaibicansmannanMana1-2Manα1-3Manα1-2Manα12Mana1Manc1-Core-GlcNAcβ1-4GIcNAcβ1-AsnManβ1-2Manα1-2Manα1-2Manα1Doesthishigh-MannosestructurebindtoMBPwithhighaffinityofnot?
Does this high-Mannose structure bind to MBP with high affinity of not?!
4 The mannose receptor helpsmacrophages to internalize pathogens
4 The mannose receptor helps macrophages to internalize pathogens