2.5 Proteoglycans(蛋白聚糖）are heavilyO-glycosylated proteins that givestrength to the extracellular matrix
2.5 Proteoglycans(蛋白聚糖) are heavily O-glycosylated proteins that give strength to the extracellular matrix
.Proteoglycans bind water, but they providestructure rather than lubrication. O-linked glycans of a mucin is small: Glycans attached to proteoglycans are verylarge, containing as many as 100 residues. Linear chains consisting of alternating aminosugars and hexopyranosides: Names of glycosaminoglycans (GAG) reflectthe tissue originally isolated
• Proteoglycans-bind-water,-but-they-providestructure-rather-than-lubrica7on- • O9linked-glycans-of-a-mucin-is-small- • Glycans-a>ached-to-proteoglycans-are-verylarge,-containing-as-many-as-100-residues- • Linear-chains-consis7ng-of-alterna7ng-aminosugars-and-hexopyranosides • Names-of-glycosaminoglycans-(GAG)-reflectthe-7ssue-originally-isolated-
AunitBunitProteincoreLinkageTissuesGlycosaminoglycanNoGlcAGIcNAcNoneConnectivetissues,skinHyaluronic acidcartilagesynovialfluid透明质酸GlcAGalNAcYesO-XyloseChondroitin sulphateCartilage, cornea, bone,skin,arteries硫酸软骨素YesO-XyloseDermatan sulphateGlcA/ldoAGalNAcSkin,bloodvesselsheartvalves硫酸皮肤素GlcNAcYesO-XyloseGlcA/ldoALung,arteries,Heparan sulphatecellsurfaces硫酸乙酰肝素GalYesN-GIcNAcCartilage,corneaKeratan sulphateGlcNAc硫酸角质HHCOOHHLOHOHOHOOHOHHOHOGalβ1-3Galβ1-4Xyl1-SerHCOO-OHOHGlyHHHHO-Xylose linkage regionD-Glucuronic acidL-lduronic acid(GlcA)(ldoA)Hyalin(透明素）membrane,cartilage（软骨),and skin
透明质酸 硫酸软骨素 硫酸皮肤素 硫酸乙酰肝素 硫酸角质 Hyalin-(透明素)-membrane,-car7lage-(软骨),-and-skin
.Two major classes: those found in extracellularmatrixandthoselocatedinplasmamembranes. Those found in structure tissues are bestunderstood:e.g.cartilage(软骨)。Thecollagen（胶原蛋白)fibresofcartilageprovidestiffness (resistance to bending) and strength(resistance to pulling)·Proteoglycans provide resilience(弹性),resistantto compression(压缩)underpressure This function depends on a high degree ofsupramolecularorganization
• Two-major-classes:-those-found-in-extracellularmatrix-and-those-located-in-plasma-membranes- • Those-found-in-structure-7ssues-are-bestunderstood:-e.g.-car7lage-(软骨)- • The-collagen-(胶原蛋白)-fibres-of-car7lage-provides7ffness-(resistance-to-bending)-and-strength- (resistance-to-pulling)- • Proteoglycans-provide-resilience(弹性),-resistantto-compression-(压缩)-under-pressure- • This-func7on-depends-on-a-high-degree-ofsupramolecular-organiza7on-
CollagennmOnly glyProeasyOnlyglyOnlvalychempolymerproject.wikispaces.com
chempolymerproject.wikispaces.com Collagen(