C.Be richinhemoglobin (Hb)-normalvaluesmale120-150g/Lfemale105-135g/L--Functioncombine with and transfer oxygen (O,) andcarbondioxide (CO,) between the lungs and tissuesCombinedwithO2orCO2,hemoglobinformsoxyhemoglobinorcarbaminohemoglobin,respectivelyThe reversibility of these combinations is the basis forthegas-transporting capability ofhemoglobin11
11 C. Be rich in hemoglobin (Hb) -normal values ◆ male 120-150g/L ◆ female 105-135g/L -Function ◆ combine with and transfer oxygen（O2）and carbondioxide （CO2） between the lungs and tissues. ◆ Combined with O2 or CO2, hemoglobin forms oxyhemoglobin or carbaminohemoglobin , respectively. ◆ The reversibility of these combinations is the basis for the gas-transporting capability of hemoglobin
E.Reticulocytesnotfullymatureerythrocytesmake up 0.5 ~1% of a totalnumber oferythrocytespopulationor3-6%inneonatenonucleusCantainribosomalRNAremnants-delicatenetworkstructureincytoplasmwhenstainedwithbrilliantcresylblueremaininghemoglobinsynthesis capacitywill disappearafter1-3daysLifespanofRBCssurvive in the circulation for about 120 days12
12 E. Reticulocytes v not fully mature erythrocytes v make up 0.5 ~1% of a total number of erythrocytes v population or 3-6% in neonate v no nucleus v Cantain ribosomal RNA remnants - delicate network structure in cytoplasm when stained with brilliant cresyl blue v remaining hemoglobin synthesis capacity, will disappear after 1-3 days Life span of RBCs survive in the circulation for about 120 days
Residual-RibosomalRNADelicatenetworkstructureincytoplasmwhenstainedwithbrilliantcresylblue13
13 Residual Ribosomal RNA v Delicate network structure in cytoplasm when stained with brilliant cresyl blue
14macrophage phagocytoses Worn-out red blood cells
14 macrophage phagocytoses Worn-out red blood cells • 图5 巨噬细胞吞噬红 细胞扫描电镜图
SickleredcelldiseaseScanningelectronmicrographofa distorted15erythrocytefromaperson(sicklecelldisease)
15 Sickle red cell disease v Scanning electron micrograph of a distorted erythrocyte from a person (sickle cell disease)