AUTOCRINE SIGNALING (3)Cell surface receptors and signal Extracellular transduction system Y Target sites on same cell PARACRINE SIGNALING General patterns of intercellular signaling ENDOCRINE SIGNALING Blood vessel Hormone secretion into blood by endocrine gland Distant target cells
General patterns of intercellular signaling (3).Cell surface receptors and signal transduction system
I Extracellular matrix. ECM 细胞外基质 Laminin Collagen Fibronectin Proteoglycan Integr 材称
Ⅱ. Extracellular matrix, ECM 细胞外基质
Major components of ECM: 1. fibrous structural proteins: collagen胶原蛋白 elastin弹性蛋白 2. adhesive glycoproteins: fibronectin纤连蛋白 laminin层连蛋白 3. proteoglycans and hyaluronan glycosaminoglycan:粘多糖 heparan sulfate, dermatan sulfate
Major components of ECM： 1.fibrous structural proteins： collagen 胶原蛋白 elastin 弹性蛋白 2.adhesive glycoproteins： fibronectin 纤连蛋白 laminin 层连蛋白 3.proteoglycans and hyaluronan glycosaminoglycan：粘多糖 heparan sulfate、dermatan sulfate
ECM occurs in two basic forms interstitial matrix and basement membrane SitTE-Integrins Fibroblast BASEMENT MEMBRANE Type IV collagen Integrins Laminin Endothelial cells Adhesive Proteoglycan glycoproteins Integrins Fibroblast Proteoglycan INTERSTITIAL MATRIX Type IV collagen Fibrillar collagens Elastin Laminin Proteoglycan and Cross-linked hyaluronan collagen triple helices Proteoglycan
ECM occurs in two basic forms: interstitial matrix and basement membrane
令Ro| es of the ecm 1. Mechanical support for cell anchorage 2. Control of cell growth 3. Maintenance of cell differentiation 4. Scaffolding for tissue renewal 5. Establishment of tissue microenvironments 6. Storage and presentation of regulatory molecules
❖ Roles of the ECM 1. Mechanical support for cell anchorage 2. Control of cell growth 3. Maintenance of cell differentiation 4. Scaffolding for tissue renewal 5. Establishment of tissue microenvironments 6. Storage and presentation of regulatory molecules