The Nobel Prize in Chemistry 2008 for the discovery and development of the green fluorescent protein, GFP Photo: J Photo: J Henriksson/SCANPIX photo: UCSD Henriksson/SCANPIX Osamu shimomura Martin Chalfie Roger y. Tsien 91/3 of the prize 9 1/3 of the prize 91/3 of the prize Marine Biological Columbia University University of California Laboratory (MBL) New York, NY USA San Diego, CA, USA Woods Hole, MA, USA Boston University Medical School Massachusetts, MA, USA
GFP and other FPs(fluorescent proteins) EGFP EYFP EBFP ECFP oo"so"60060"7b"7o
GFP and other FPs (fluorescent proteins)
The Nobel Prize in chemistry 2009 for studies of the structure and function of the ribosome photo: U, Montal photo: U. Montan photo: U, Montan Venkatraman Thomas A steitz Ada e. yonath Ramakrishnan o 1/3 of the prize o 1/3 of the prize O 1/3 of the prize United Kingdom Israel MRC Laboratory of Yale University Weizmann Institute of Molecular Biology New Haven, CT, USA Science Rehovot, israel Kingdom Institute b.1952 b.1940 b.1939 (in Chidambaram, Tamil
The Nobel Prize in Physiology or Medicine 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase photo: U. Montan photo: U Montan photo: U. Montan Elizabeth h Carol w. Greider Jack W. Szostak Blackburn 91/3 of the prize ①1/3 of the prize ①1/3 of the prize USA USA University of California Johns Hopkins Univers Harvard Medical Schor San Francisco, CA, USA School of Medicine Massachusetts General Baltimore, MD, USA Hospital Howard Hughes Medical b,1948 b,1961 b,1952 in Hobart Tasmania (in London, United Australia)
Telomere DNA protects the chromosomes The telomeres form caps at the ends of chromosomes. They contain a unique DNA sequence which is repeated several times (Telomeres: from the Greek for end"telos and"part" meros) Telomere DNA i Telomeres built base by base The DNA sequence varies sightly RNA template between spedes. The one shown Chromosomes here is from Tetrahymena Cell LMACCCCAACCCCAACCECAACCCCAA Telomere DNA Telomerase Protein 51TG604116 CCCEAAC The enzyme S 3 Telomerase operates at the end of the chromosome. It s an enzyme consisting of a protein and an RNA component. The RNA serves as a template for synthesizing telomere DNA
Telomere DNA protects the chromosomes