Phosphory lation(CheA, CheY, che B) Chea (protein kinase), uses aTP to phosphorylate one of its histidines cheatatpechea +Adp CheA (CheApis bound to the Tar receptor through an adapter protein CheW. CheW is not known to have any enzymatic activity ( these proteins are sometimes called scaffolding protein) Chea is unstable and transfers its phosphoryl group to CheY(highly soluble diffuses through the cytoplasm
I Phosphorylation (CheA, CheY, CheB) CheA (protein kinase), uses ATP to phosphorylate one of its histidines. ADP p CheA + ATP ↔ CheA + CheA (CheAp)is bound to the Tar receptor through an adapter protein CheW. CheW is not known to have any enzymatic activity. (these proteins are sometimes called ‘scaffolding protein’) CheAp is unstable and transfers its phosphoryl group to CheY (highly soluble, diffuses through the cytoplasm
CheA His48 Falke. J J.R.B. Bass. S.L. Butler s.A. Chervitz, and m.A. danielson The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors,kinases, and adaptation enzymes. Annu Rev cell Dev Bio/ 13(1997): 457-512 Courtesy of Annual Review of Cell and Developmental Biology. Used with permission
CheA His48 Courtesy of Annual Review of Cell and Developmental Biology. Used with permission. Falke, J. J., R. B. Bass, S. L. Butler, S. A. Chervitz, and M. A. Danielson. "The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes." Annu Rev Cell Dev Biol 13 (1997): 457-512