Basic concepts of monogenic ◆Abbreviations P=parents being crossed F1=children of the crossed P F2=children from F1's(grandchildren of original P) ■X=cross
◼ P = parents being crossed ◼ F1 = children of the crossed P ◼ F2 = children from F1’s (grandchildren of original P) ◼ X = cross Basic concepts of monogenic ◆ Abbreviations
Research methods of monogenic Pedigree:a genetic disease patients family members of disease in a chart,is an important means of human genetics study. Pedigree analysis through the pedigree,according to genetic law is analyzed its phenotype and genotype, the initial judgment for a single gene disease hereditary disease or gene mapping
Research methods of monogenic ◆ Pedigree: a genetic disease patients family members of disease in a chart, is an important means of human genetics study. ◆ Pedigree analysis : through the pedigree, according to genetic law is analyzed its phenotype and genotype, the initial judgment for a single gene disease hereditary disease or gene mapping
◆Pedigree Proband (Index case)
Ⅰ Ⅱ 1 2 1 2 3 ◼ Proband (Index case) ◆ Pedigree
Standard symbols used in pedigrees Male Heterozygotes for autosomal recessive Female Carrier of x-linked recessive Mating Death Parents Abortion or stillbirth; and children sex unspecified (1boy,1 girl) in order of birth (elder on left) o9 Propositus(-ta） Dizygotic twins Method of identifying persons in a pedigree: Monozygotic twins Propositus is child 2 in generation 2 Sex unspecified Number of children Consanguineous 4 5 of sex indicated marriage Affected individuals Divorce
Standard symbols used in pedigrees
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