Medical Genetics Multifactorial Disease
Multifactorial Disease Medical Genetics
Emphasis Qualitative trait Quantitative trait Characteristics of Polygenic Inheritance *Threshold Theory *Heritability Estimate of Heritability 必 Inheritance Characteristics of Polygenic Disease Estimate of Recurrence Risk
❖ Qualitative trait & Quantitative trait ❖ Characteristics of Polygenic Inheritance ❖ Threshold Theory ❖ Heritability & Estimate of Heritability ❖ Inheritance Characteristics of Polygenic Disease ❖ Estimate of Recurrence Risk Emphasis
Major gene Minor gene Additive effect Additive gene Polygenic inheritance Multifactorial inheritance Multifactorial traits are those which result from an interaction between multiple genes and often multiple environmental factors
Major gene & Minor gene Additive effect & Additive gene Polygenic inheritance Multifactorial inheritance Multifactorial traits are those which result from an interaction between multiple genes and often multiple environmentalfactors
Qualitative Trait Monogenic t女ait 120cm 165cm aa AA OR Aa Height of pituitary dwarfism normal
Qualitative Trait Monogenic trait 120 cm 165 cm aa AA OR Aa Height of pituitary dwarfism & normal
Qualitative Trait Monogenic trait 05% 4550% 100% aa Aa AA PAH activity of PKU carrier normal
Qualitative Trait Monogenic trait 0~5 % 45~50 % 100 % aa Aa AA PAH activity of PKU、carrier & normal