补体系统( complement system) Antigen-antibody (gG or IgM) CLASSIC PATHWAY complex Classic pathway Activated C1 C3 convertase Classic pathway C5 convertase c4+C2 C4b2a C4b2a3b r Also generated via plasmin or lysosomal proteases (( s C3b Membrane attack complex CbbB Alternative pathway Alternative pathway Factor Factor C3 convertase C5 convertase Microbial surfaces B D Stabilized by Polysacchanides proper ALTERNATIVE PATHWAY
补体系统 (complement system)
凝血纤溶系统 fibrinogen XII Clotting S. thrombi n fibrinopeptide XIla 00c000 fibrin Fibrinolytic s plasmin split products 000
plasmin thrombi n fibrin fibrinogen XII XIIa Clotting s. Fibrinolytic s. n split products fibrinpeptides 凝血纤溶系统
HAGEMAN FACTOR kallikrein Factor XE plasmin ACTIVATED ACTIVATED CLOTTING CLOTTING SYSTEM STEM fibl aslin fibrino peptides ACTIVATED KININ SYSTEM kinin COMPLEME degradat products 中 AGMEN Cl esteraes 3 Es ACTIVATED COMPLEMENT SYSTEM
HAGEMAN FACTOR Factor XI ACTIVATED CLOTTING SYSTEM fibrin + fibrinopeptides Fibrin degradat ion products C1 C1 esteraes C3 C5 ACTIVATED COMPLEMENT SYSTEM ACTIVATED KININ SYSTEM kinin kallikrein plasmin ACTIVATED CLOTTING SYSTEM plasmin C3 C5 COMPLEMEN T FRAGMENTS
炎症介质 介质扩张血管通透性趋化作用其它 缓激肽+ 疼痛 组胺 C3a 调理 C5a C3b C3bi 前列腺素+ 疼痛发热
炎症介质 介质 扩张血管 通透性 趋化作用 其它 缓激肽 + + - 疼痛 组胺 + + - C3a > + - 调理 C5a > + + C3b C3bi 前列腺素 + > - 疼痛 发热
炎症介质(续) 介质扩张血管通透性趋化作用其它 白细跑三烯B4 C4 D4 E4 支气管/血管收缩 o代谢产物 十/-组织损伤 PAF +支气管收缩 IL-1 TNF +发热 NO 细胞毒性作用
炎症介质(续) 白细胞三烯B4 - - + C4 D4 E4 - + - 支气管/血管收缩 O代谢产物 - + +/- 组织损伤 PAF - + + 支气管收缩 IL-1 TNF - - + 发热 NO + 细胞毒性作用 介质 扩张血管 通透性 趋化作用 其它