Section B Thrombosis Thrombus Thrombi
Thrombosis Thrombus Thrombi
ANTITHROMBOTIC PROPERTIES Inhibition of platelet aggregation: PGI NO. ADPase Anticoagulant-binding and inhibition of thrombin: Antithrombin ii acceleration by heparin-like molecules, thrombomodulin activation of protein C/S, a2-macroglobulin. Fibrinlysis: Tissue plasminogen activator(tPA)
ANTITHROMBOTIC PROPERTIES • Inhibition of platelet aggregation: PGI2, NO, ADPase • Anticoagulant -binding and inhibition of thrombin: Antithrombin III acceleration by heparin-like molecules, thrombomodulin activation of protein C/S, 2 -macroglobulin. • Fibrinlysis: Tissue plasminogen activator (tPA)
PROTHROMBOTIC PROPERTIES Simulation of platelet aggregation (adhesion): von Willebrand factor, platelet-activating factor. Procoagulation factors: Tissue factor, binding factors IXa and Xa, Factor V. Inhibition of fibrinolysis: t-PA inhibitor
PROTHROMBOTIC PROPERTIES • Simulation of platelet aggregation (adhesion): von Willebrand factor, platelet-activating factor. • Procoagulation factors: Tissue factor, binding factors IXa and Xa, Factor V. • Inhibition of fibrinolysis: t-PA inhibitor
2shape chang 3Gnmuerul 0Pateetan (ADP, TXA) THrombin actator Tranomaro o tactor clocks coaglation
• Fig 5-5
FAVOR THROMBOSIS INHIBIT THROMBOSIS Extrinsic coagulation Inactivates thrombin, lactors Xa, IXa factors Va and villa ActiveproteinC-,ProteinC Exposure of membrane-bound Inhibit platelet tissue factor aggregation Platelet adhesion. Antithrombin Ill Held together by VWF PGl2, NO and Fibrinogen adenosine d phosphatase H lke Thrombomodulin molecule
• Fig 5 - 6