Section C CELL DEATH
CELL DEATH
Common type of necrosis after exogenous stimuli。 Swelling, denaturation and coagulation of proteins Breakdown of cellular organelles Cell rupture
• Swelling, denaturation and coagulation of proteins • Breakdown of cellular organelles • Cell rupture Common type of necrosis after exogenous stimuli
NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ Denaturation of proteins. Enzymatic digestion of organelles and cytosol
NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ: • Denaturation of proteins. • Enzymatic digestion of organelles and cytosol
AUTOLYSIS Enzymatic digestion by lysosomal enzymes of the dead cells themselves HETEROLYSIS Digestion by lysosomal enzymes of immigrant leukocytes
•Enzymatic digestion by lysosomal enzymes of the dead cells themselves. AUTOLYSIS HETEROLYSIS • Digestion by lysosomal enzymes of immigrant leukocytes
Three pattern of nuclear changes Karyolysis(DNase activity) Pyknosis ( dna condensation) Karyorrhexis(fragmentation of pyknotic nucleus)
Three pattern of nuclear changes Karyolysis (DNase activity) Pyknosis (DNA condensation) Karyorrhexis (fragmentation of pyknotic nucleus)