General structures Structure characteristics Steroid skeleton Steroid compounds have a cyclo pentanoperhydrophenanthrene skeleton. Some of these drugs are natural products, and some are synthetic materials. Most of these drugs are obtained by semi-synthetic methods Section l
General structures C C ➢ Structure characteristics Steroid skeleton: Steroid compounds have a cyclopentanoperhydrophenanthrene skeleton.Some of these drugs are natural products,and some are synthetic materials.Most of these drugs are obtained by semi-synthetic methods. Section 1
Sort Structure ypical drugs CHOH C=。 Hydrocortisone Acetate Adrenocorticoid HO H (醋酸氢化可的松) hormones Dexamethasone Acetate (醋酸地塞米松); OH Methyltestosterone (甲睾酮); Androgens Testosterone Propinate (丙酸睾酮);
Sort Structure Typical drugs Adrenocorticoid hormones Hydrocortisone Acetate (醋酸氢化可的松）; Dexamethasone Acetate （醋酸地塞米松）; Androgens Methyltestosterone （甲睾酮）; Testosterone Propinate （丙酸睾酮）; O HO C O CH2 OH H O OH
<Previous OCOCH CH-CH Alair anabolic Nandrolone Phenylpropionate hormones (苯丙酸诺龙) Progesterone: o Megestrol Acetate Progestogens (醋酸甲地孕酮); Norethisterone (炔诺酮) OH Estradiol Ethinylestradiol Estrogens (炔雌醇) HO Diethylstibestrol (己烯雌酚)
Galair anabolic hormones Nandrolone Phenylpropionate (苯丙酸诺龙）; Progestogens Progesterone; Megestrol Acetate （醋酸甲地孕酮） ; Norethisterone （炔诺酮） ; Estrogens Estradiol; Ethinylestradiol （炔雌醇） ; Diethylstibestrol (己烯雌酚）. O O C O C H 2 C H 2 - C 6 H 5 O O C H 3 H O O H
鉴别实验 △4-3-酮基一紫外分光光度法 酮基一呈色反应(与羰基试剂呈色) 制备衍生物测定其熔点 与强酸的呈色反应 官能团一红外分光光度法 C17(-醇酮基一呈色反应(与氧化剂四氮唑盐呈色) 沉淀反应 甲基酮一呈色反应(与亚硝基铁氰化钠、间二硝基酚、芳香醛呈色) 第二芹
鉴 别 实 验 第二节 Δ4 -3-酮基 — 紫外分光光度法 C17-α-醇酮基 — 呈色反应 (与氧化剂四氮唑盐呈色) — 沉淀反应 酮基 — 呈色反应 (与羰基试剂呈色) — 制备衍生物测定其熔点 — 与强酸的呈色反应 官能团 — 红外分光光度法 甲基酮 — 呈色反应 (与亚硝基铁氰化钠、间二硝基酚、芳香醛呈色)
Identification tests △4-3-keto— Ultraviolet spectrophotometry Ketone group-Color reaction(with carbonyl reagents) Melting point determination of derivatives Reaction with strong acids Functional group-Infrared spectrophotometry a-hydroxyacetone Color reaction( with tetrazoline salt) Precipitation reaction Methylketone group- Color reaction( with sodium nitroferricyanide, m-dinitrophenol, aromatic aldehyde Section 2
Identification tests Section 2 Δ4 -3-keto — Ultraviolet spectrophotometry α-hydroxyacetone — Color reaction(with tetrazoline salt) — Precipitation reaction Ketone group — Color reaction (with carbonyl reagents) — Melting point determination of derivatives — Reaction with strong acids Functional group — Infrared spectrophotometry Methylketone group — Color reaction(with sodium nitroferricyanide , m-dinitrophenol,aromatic aldehyde )