Ach is the natural linical Chent Related compounds are agonist at the useful in the neuroscience neuromuscular research Carbachol and related O CH compounds are used CHs d Tubocurarine and othe clinically for GI disorders CH3 related compounds glaucoma, salivary CHs are used to paralyze gland malfunction, etc muscles during surgery acetylcholinestc H3 CH3 CH3 OCH3 OH NH2--C-OCH2CH2-N-CH H Carbachol CH3O OH H3C H D-Tubocurarine
17 Clinical Chemistry Ach is the natural agonist at the neuromuscular junction. Tubocurarine is the primary paralytic ingredient in curare. Tubocurarine competes with ACh for binding to receptor- but does not open the pore. So tubocurarine is a neuromuscular blocking agent. Tubocurarine and other, related compounds are used to paralyze muscles during surgery. Carbachol is a synthetic agonist not hydrolyzed by acetylcholinesterase. Carbachol and related compounds are used clinically for GI disorders, glaucoma, salivary gland malfunction, etc. Suberyldicholine is a synthetic neuromuscular agonist. Related compounds are useful in the neuroscience research
Anticholinesterase Agents >Anticholinesterase(anti-ChE) agents inhibit acetylcholinesterase(乙酰胆碱酯 酶) >prolong excitation at the nmj
18 Anticholinesterase Agents ➢Anticholinesterase (anti-ChE) agents inhibit acetylcholinesterase （乙酰胆碱酯 酶） ➢prolong excitation at the NMJ
Anticholinesterase Agents 1. Normal ACh Choline t Acetate AChE 2. With anti-AchE ACh >Choline Acetate anti-AChr
19 1. Normal: ACh Choline + Acetate AChE 2. With anti - AchE: ACh Choline + Acetate anti - AChE Anticholinesterase Agents
Uses of anti-ChE agents Clinical applications( Neostigmine,新斯的明, Physostigmine毒扁豆碱) ≯ Insecticides( organophosphate有机磷酸酯) ≯ Nerve gas(eg. Sarin沙林,甲氟膦酸异丙酯 种用作神经性毒气的化学剂)
20 Uses of anti-ChE agents ➢Clinical applications (Neostigmine, 新斯的明, Physostigmine毒扁豆碱) ➢Insecticides (organophosphate 有机磷酸酯) ➢Nerve gas (e.g. Sarin 沙林，甲氟膦酸异丙酯。 一种用作神经性毒气的化学剂))
Sarin and Aum Shinrikyo(奧姆真理教) Aum Shinrikyo(奥姆真理教)isa Japanese religious cult obsessed with the apocalypse(启示,天启) The previously obscure group became infamous in 1995 when some of its members released deadly sarin nerve gas into the Tokyo subway system killing 12 people and sending more than 5, 000 others to hospitals
21 Sarin and Aum Shinrikyo(奥姆真理教) ➢ Aum Shinrikyo(奥姆真理教) is a Japanese religious cult obsessed with the apocalypse （启示，天启）. ➢ The previously obscure group became infamous in 1995 when some of its members released deadly sarin nerve gas into the Tokyo subway system, ➢ killing 12 people and sending more than 5,000 others to hospitals