能 lon channels and AP ca. INa-Ca 0 K1 3 K1 人民只生公版松
Ion channels and AP 0 1 2 3 4 INa ICa.L IKr IKs IK1 IK1 ITo1 INa-Ca
心室肌细胞AP的形成 个个个个个 INa Slow inward Ca++current 0 Outward CI-current Ic 3 W Membrane Na+/K+ATPase Outward K+currents Na* (To IKuri Ikr Iks;IK1) k14 Rapid inward ↓ Na*current (INa) 人凤只坐公版松
心室肌细胞AP的形成 Rapid inward Na+ current ( INa ) 0 INa Membrane Na+ /K+ ATPase Na + K + 2 ICa Slow inward Ca++ current ICa 1 ITo 3 IKr IKs IKur IK1 4 IK1 Outward K+ currents (ITo ; IKur ; IKr ; IKs ; IK1) ICl Outward Cl- current ICl
lon currents underlying AP in ventricle Inward currents Possible clone Blockers INa SCN5A TTX,STX,lidocaine DHP receptor DHP,Cd2+,Co2+ NCX1 Ni+,NCX1-antibody Outward currents Kir2.x Ba2+ Kv4.x 4-AP 10 -12 ? DIDS,9-AC HERG/MiRPI Dofetilide,sotalol IKs KvLQT1/minK Chromanol 293B 人凤只生公松
Ion currents underlying AP in ventricle Inward currents INa ICa INa/Ca Outward currents IK1 Ito1 IKr IKs Ito2 ITO SCN5A DHP receptor NCX1 Kir2.x Kv4.x ?? HERG/MiRP1 KvLQT1/minK Possible clone TTX, STX, lidocaine DHP, Cd2+, Co2+ Ni +, NCX1-antibody Ba2+ 4-AP DIDS, 9-AC Dofetilide, sotalol Chromanol 293B Blockers
普肯耶细胞动作电位时程中的主要参与电流 inward outward Phase 4 Na+current Ca2+ 「L-type The time course of current T-type TO (4-AP-sensitive) the currents in the current ITo2 (Ca2-activated) Iks action potential of delaved e His-Purkinje cells lat or lkp inward rectifier,Ik pacemaker current,I; (,..,see above】 Na-Ca2+exchange Na',K'-ATPase 人民只生B版松
普肯耶细胞动作电位时程中的主要参与电流 The time course of the currents in the action potential of His-Purkinje cells
显 窦房结细胞动作电位时程中的参与电流 INa/Ca I Ca(L) I:f Ik Ica(T) Currents underlying depolarization in SA nodal cells 人凤只坐公版松
Currents underlying depolarization in SA nodal cells 窦房结细胞动作电位时程中的参与电流