Design of Microfluidics-Based Biochips Evangeline F.Y.Young Mixed Droplet Photodiode Electrical Pad LED Mixing Sample Electrowetting Electrode Reagent Slides partly adopted from Krishnendu Chakrabarty of Duke University 1
Design of Microfluidics-Based Biochips Evangeline F.Y. Young Slides partly adopted from Krishnendu Chakrabarty of Duke University 1 Slides partly adopted from Krishnendu Chakrabarty of Duke University
Motivation for Biochips Clinical diagnostics,e.g.,healthcare for premature infants,point-of-care diagnosis of diseases "Bio-smoke alarm":environmental monitoring Massive parallel DNA analysis,automated drug discovery,protein crystallization CLINICAL DIAGNOSTIC Lab-on-a-chip for APPLICATION CLINICAL DIAGNOSTICS Shrink Microfluidic Lab- on-a-Chip HttitiHitii 20nl sample Higher throughput,minimal human intervention, smaller sample/reagent consumption,higher Conventional Biochemical Analyzer sensitivity,increased productivity 2
Motivation for Biochi p s • Clinical diagnostics, e.g., healthcare for premature infants, point-of-care diagnosis of diseases • “Bio-smoke alarm”: environmental monitoring • Massive parallel DNA analysis, automated dru g y, p y discovery, protein cr ystallization Shrink CLINICAL DIAGNOSTIC APPLICATION Lab-on-a-chip for CLINICAL DIAGNOSTICS Microfluidic Labon-a-Chip 20nl sam ple Conventional Biochemical Analyzer Higher throughput, minimal human intervention, smaller sample/reagent consumption, higher sensitivity, increased productivity 2 Conventional Biochemical Analyzer sensitivity, increased productivity
Motivation for Biochips Disease related mortality is the No.1 bottleneck for Aquaculture industry. Biochip can be used for fish disease testing. Laboratory Biochip Sample Processing 1 hr 30 min 5min PCR Response 3hr 1 hr 15 min Analysis 30 min 10 min Total 5hr 1 hr 30 min
Motivation for Biochi p s • Disease related mortality is the N 1 b ttl k f A lt No. 1 b ottlenec k for Aquaculture industry. • Biochip can be used for fish Biochip can be used for fish disease testing. L ba boratory Bi hi oc p Sample Processing PCR Response 1 hr 30 min 3 hr 5 min 1 hr 15 min Response Analysis Total 30 min 5 hr 10 min 1 hr 30 min
Tubes to Chips:BioChips Driven by biomolecular analysis needs Agilent DNA analysis Lab on a Chip(1997) Test tube analysis 4
Tubes to Chip p s: BioChips • Driven by biomolecular analysis needs T tt b l i Agilent DNA analysis Lab on a Chip (1997) 4 Test tube analysis
Motivation for Microfluidics ▣Automation Test tubes ▣Integration ☐Miniaturization Automation Robotics Integration ▣Miniaturization Automation Microfluidics Integration ☒Miniaturization 5
Motivation for Microfluidics T tt b Automation Test tu bes Integration Miniaturization Robotics Automation Integration Miniaturization Microfluidics Automation Integration Miniaturization 5