《影响人类历史进程的100名人排行榜》弗莱明列第45位 Thanks to PENICILLIN ..He Will Come Home It is now known that the target of the penicillins are the penicillin binding proteins transpeptidases. 名卷 Sir Alexander Fleming Ernst Boris Chain Sir Howard Walter Florey
The Penicillin Project Florey and Chain each brought scientific knowledge and talent to the effort that filled out the other's contribution,but the two were mismatched in terms of their personalities. ·青霉素的继续开发需要一个完整的团队 牛津大学成廉敦病理学院 In 1935,Howard Florey (1898-196)became head of the Sir William Dunn School of Pathology at Oxford.Florey,an Australian-born pathologist,wanted a top-notch biochemist to help him with his research,and asked Hopkins for advice.Without hesitation,Hopkins suggested Chain
Tryothricin Is Early than Penicillin Rene Jules Dubos (1901-1982) 短杆菌肽 Tyrothricin was reported in NY meeting in Sep 1939 Tyrothricin--the first natural antibiotic discovered through a deliberate, systematic search for antibacterial compounds 1942年，Dub0s预言由于抗生素的应用会导致耐药菌的产生
1948 Albert Lasker Basic Medical Research Award Vincent du Vigneaud 1955 NP Selman A.Waksman Rene J.Dubos(1901-1982) Cornell University Medical College (1888-1973)1952 NP The Rockefeller Institute Dr.du Vigneaud worked intensively on the chemistry of biochemically important sulphur compounds,especially for the first synthesis of a polypeptide hormone-Oxytocin催产素
Enter Howard Florey “青霉素之父” YEA EO1801 "In terms of world well-being,Florey was the Robert Menzies 1898-1968 most important man ever born in Australia." 1894-1978 "I became interested-immediately-in Fleming's paper,not because I hoped to discover a miraculous drug for the treatment of bacterial infection which for some reason had been overlooked,but because I thought it had great scientific interest