3.药物一源于偶然发现 Serendipity in Drug Discovery:Penicllin
A Story Has Been Told A Thousand And One Times Who?When?discovered penicillin? How was penicillin discovered? If had not a mould accidently entered Fleming's Lab.,What will happen? What do you think:approximately 14 years elapsed between Sir Alexander Fleming's discovery and its full-scale production for therapeutic use in 1942? If Penicillin was discovered in 1928,Without the brilliance of Sulfanilamide? Who won Nobel Prize for Discovering Penicillin? Who will be next one of Penicillin team if no limite? If Fleming was a great scientist? How many“By chance”in this story? It is a fortunate stroke of serendipity or a chance reward for tenacity? Who was the first discovering the antibacterial properties of the Penicillium fungus?
Serendipity Finding “Chance favors the prepared mind” COOH Alexander Fleming A famous petri dish (1881-1955) Alexander Fleming discovered penicillin in 1928 but 1943 in clinic. The first real breakthrough in the field of anti-infectives was the discovery of the B-lactam antibiotics such as penicillin G. H.W.Florey got crud Penicillin in 1940 and put it into clinic use. Penicillin was difficult to grow in bulk and it would be needed in large quantities to work
The Mystery of the Plate Why was Fleming unable to make penicillin into an antibiotic available to all who needed it? -Peniciltium colony -Area of inhibition of bacterial growth Normal bacterial colony Penicillium notatum 1928年9月的一天早晨，度假回来的 Fleming偶然发现在贴有葡萄球菌的标签的培 养基发了霉，长出一团青色的霉花，在其周 围还有一小圈空白的区域，原来生长的葡萄 状球菌消失了。Fleming?意识到这种青霉菌有 可能就是葡萄球菌的克星
War and Penicillin-A Life-Saving Drug Penicillin helped win World War II,be hailed as "Miracle Drugs