山羊豆碱 Galegine H2N、NH2 NH French diabetologist Galega officinalis Jean Sterne
John M.Daly博士-蟾蜍毒素之父 OH HO HO batrachotoxin batrachotoxin A 'Frog Man‘ John William Daly (1933-2008) Golden poison frog,The most toxic of poison dart frog species is Phyllobates terribilis Daly (r)poses with former postdoctorul fellow Kenneth Seamon in 1983,shortly after they discovered that forskolin was a powerful research tool
Batrachotoxin箭毒蛙毒素 HO HO John William Daly Phyllobates terribilis Isolated,purified,and characterized (1933-2008) in 1963;structure was determined in 1968 金色箭毒蛙(Golden Poison Frog)是箭毒蛙 中毒性最强的一种，它的身体没有一个瓶盖大， 但其毒性却足以杀死20000只老鼠或10个成年人。 Bernhard Witkop (1917-2010)
Batrachotoxin箭毒蛙毒素 HO HO HO HO Batrachotoxin A Batrachotoxin 箭毒蛙毒素(BTX)是1963年美国NIH科学家John W.Daly (1933-2008)和Bernhard Witkop(1917-2010)从哥伦比亚北部雨林毒蛙 分离出的，1968年通过X-衍射确定了batrachotoxinin A的结构，通过 比较二者的核磁谱和质谱数据，1969年确定了箭毒蛙毒素的结构
Where Did Our Drugs Come From? New morphine comes from frogs Epibatidine The skin of the phantasmal 地棘蛙素 poison frog contains epibatidine 'Frog Man Amphibian skin has provided a wide range of biologically active alkaloids.During the past 30 years,>400 alkaloids of>20 structural classes have been detected by Daly.Total 800 Amphibian alkaloids reported. Epibatidine was discovered by John W.Daly in 1974.The structure of epibatidine was elucidated in 1992.About 28 structural classes of alkaloids are known in poison frogs