Free radicals: Injury induced by free radicals
Free Radicals: Injury induced by free radicals O2
(1)Free radical Free radical--atoms, molecules or ions with unpaired electrons on an otherwise open shell configuration These unpaired electrons are usually highly reactive, so radicals are likely to take part in chemical reactions 1)Oxygen free radical 2 Lipid radical
(1) Free radical Free radical——atoms, molecules or ions with unpaired electrons on an otherwise open shell configuration. These unpaired electrons are usually highly reactive, so radicals are likely to take part in chemical reactions. 1)Oxygen free radical 2)Lipid radical
(2)Oxygen free radical, OFR Types (1)the superoxide anion(O2) (2 the hydroxyl radical (oH (3 singlet oxygen (102) (4 hydrogen peroxide(H2O2)
(2) Oxygen free radical, OFR Types： (1)the superoxide anion (O2 -) (2)the hydroxyl radical (OH ·) (3)singlet oxygen (1O2 ) (4)hydrogen peroxide (H2O2 )
(3)Lipid free radicals; The interaction of oxygen free radicals with polyunsaturated fatty acids in the phospholipids of cell membrane leads to the formation of lipid free radicals Types 1) Fatty acid radical (lL 2)Lipid peroxide (LOO) (4)Others: Cl, CH3 NO
(3) Lipid free radicals： The interaction of oxygen free radicals with polyunsaturated fatty acids in the phospholipids of cell membrane leads to the formation of lipid free radicals. Types： 1) Fatty acid radical (L·) 2) Lipid peroxide（LOO·） (4) Others: Cl·, CH3·, NO·
(5)Generation and elimination of oxygen free radicals 1)Origin of"2: a mitochondria b. Oxidation of some chemicals in body. C Catalysis by enzymes d stimulation of cells with toxins
(5) Generation and elimination of oxygen free radicals 1) Origin of O·- 2： a. Mitochondria b. Oxidation of some chemicals in body. c. Catalysis by enzymes d. Stimulation of cells with toxins