Molecular regulation of Development Growth factor signaling, Hox genes and the body plan 张咸宁 zhangxianning@zju.edu.cn Tel:13105819271;88208367 Office: A705, Research Building 2012/09
Molecular Regulation of Development. Growth factor signaling, Hox genes and the body plan 张咸宁 zhangxianning@zju.edu.cn Tel：13105819271; 88208367 Office: A705, Research Building 2012/09
出生缺陷( Birth defect):即先天性疾病 Malformation is a primary morphologic defect of an organ or body part resulting from an intrinsically abnormal developmental process(e. g. cleft lip, polydactyly) Dysplasia is a primary defect involving abnormal organization of cells into tissue(e. g, vascular malformation). Sequence is a primary defect with its secondary structural changes(e. g Pierre robin sequence, a disorderin which a primary defect in mandibular development produces a smalljaw, secondary glossoptosis, and a cleft palate Syndrome is a pattern of multiple primary malformations with a single etiology(e.g, trisomy 13 syndrome). Deformation is alteration of the form, shape, or position of a normall formed body part by mechanical forces. It usually occurs in the fetal period not in embryogenesis. It is a secondary alteration. It can be extrinsic, as in oligohydramnios(reduced amniotic fluid), or intrinsic, as in congenital myotonic dystrophy. Disruption is a morphologicaldefect of an organ, part of an organ, or a larger region of the body resulting from the extrinsic breakdown of, or interference with, an originally normal developmental process. It is a secondary malformation(e.g, secondary limb defect resulting from a vascular event)
出生缺陷（Birth defect）：即先天性疾病 • Malformation is a primary morphologic defect of an organ or body part resulting from an intrinsically abnormal developmental process (e.g., cleft lip, polydactyly). • Dysplasia is a primary defect involving abnormal organization of cells into tissue (e.g., vascular malformation). • Sequence is a primary defect with its secondary structural changes (e.g., Pierre Robin sequence, a disorder in which a primary defect in mandibular development produces a small jaw, secondary glossoptosis, and a cleft palate) • Syndrome is a pattern of multiple primary malformations with a single etiology (e.g., trisomy 13 syndrome). • Deformation is alteration of the form, shape, or position of a normally formed body part by mechanical forces. It usually occurs in the fetal period, not in embryogenesis. It is a secondary alteration. It can be extrinsic, as in oligohydramnios (reduced amniotic fluid), or intrinsic, as in congenital myotonic dystrophy. • Disruption is a morphological defect of an organ, part of an organ, or a larger region of the body resulting from the extrinsic breakdown of, or interference with, an originally normal developmental process. It is a secondary malformation (e.g., secondary limb defect resulting from a vascular event)
Three questions 1. How is dorsal-ventral(D-V背腹)cll differentiation regulated by morphogen 形态发 生素) gradients 梯度)∵BMP(骨形态发生 蛋白) signal transduction 2. Hox is the the antero- posterior(A-P前后) pattern regulated by hox genes? Colinearity(共线性) Activation by retinoic acid(视黄酸) Retinoid receptors. 3. How have conserved(保守) gene networks affected Evolution and development? Evo-Devo
Three questions: 1. How is dorsal-ventral (D-V背腹 ) cell differentiation regulated by morphogen（形态发 生素）gradients（梯度）. BMP（骨形态发生 蛋白） signal transduction. 2. Hox is the the antero-posterior (A-P前后 ) pattern regulated by Hox genes? - Colinearity（共线性） - Activation by retinoic acid（视黄酸）. Retinoid receptors. 3. How have conserved（保守）gene networks affected Evolution and Development? Evo-Devo
1. During development groups of inducing cells called organizing centers secrete graded growth factor signals. The concentration gradient of a"morphogen"can induce multiple cell differentiation choices inductive signal OOOOO ○○○o○o●●○o○○○ cells directed to new developmental pathway Figure 21-12. Molecular Biology of the Cell, 4th Edition
1. During development groups of inducing cells called organizing centers secrete graded growth factor signals. The concentration gradient of a “morphogen” can induce multiple cell differentiation choices. Fig. 1
ectoderm (epidermis ectoderm (neural plate notochord D-V patterning can blastopore lip be studied in the somites lateral plate yolk frog embryo. endoderm (B) brain spinal cord blastopore (C) Figure 21-71 part 2 of 2. Molecular Biology of the Cell, 4th Edition. Fig 2
D-V patterning can be studied in the frog embryo. Fig. 2