Hypersensitivity(超敏反应) Jianzhong chen Institute of immunology Zhejiang University School of Medicine chenjianzhong@zju.edu.cn
Hypersensitivity (超敏反应) Jianzhong Chen Institute of Immunology Zhejiang University School Of Medicine chenjianzhong@zju.edu.cn
Type II hypersensitivity cytotoxic type) a Type Ii hypersensitivity reactions are mediated by igg and igm antibody binding to specific cells or tissues. The damage caused is thus restricted to the specific cells or tissues bearing the antigen. a The antibodies damage cells and tissues by activating complement and by binding and activating effector cells carrying FcyR
Type II hypersensitivity (cytotoxic type) Type II hypersensitivity reactions are mediated by IgG and IgM antibody binding to specific cells or tissues. The damage caused is thus restricted to the specific cells or tissues bearing the antigen. The antibodies damage cells and tissues by activating complement, and by binding and activating effector cells carrying FcR
I Pathogenic mechanisms Ags on the surface of target cells body→IgG,IgM 1. damage the target cell 1) activation of complement 2) opsonization: FcR, C3bR 3)ADcc: nk cells,Mφ 2 target cell dysfunction
I. Pathogenic mechanisms Ags on the surface of target cells ↓ body→IgG, IgM ↓ 1. damage the target cell 1) activation of complement 2) opsonization: FcR, C3bR 3) ADCC: NK cells, M 2. target cell dysfunction
细胞表面固有抗原或吸附于 细胞表面的抗原、半抗原 十 相应抗体(gG、lg 激活补体 调理吞噬 NK细胞、吞噬细胞刺激或阻断作用 溶解靶细胞 吞噬破坏靶细胞 ADCC作用 靶细胞损伤 靶细胞功能改变 Ⅱ型超敏反应的发生机制
Type ll Hypersensitivity classical pathway complement activation nK cell MAC Antibody dependent cell cytotoxicity C2-C9 FeRⅢ5 macrophage opsonization
NK cell opsonization