1.Blood components Mean Corpuscular Volume (MCV): MCV (fl)=_ Hct (% -×10 RBC (x 106/ul) Mean Cellular Haemoglobin Concentration (MCHC): Hb(g/dl) MCHC(g/dl)= ×100 Hct (%
Mean Corpuscular Volume (MCV): Mean Cellular Haemoglobin Concentration (MCHC): Hct (%) RBC (x 106 /µl) MCV (fl) = × 10 Hb (g/dl) Hct (%) MCHC (g/dl) = × 100 1. Blood components
1.Blood components 一 white blood cell (WBC,leukocyte):4X103- 1×104/加l granulocyte:granules,lobed nuclei,phagocytic neutrophil:50-70% -eosinophil:0.5-3% basophile:0-1% 。agranulocyte lymphocyte:20-30% monocyte:3-8% -Platelet (thrombocytes):100-280X103/ul
– white blood cell (WBC, leukocyte): 4×103 - 1×104 /µl • granulocyte: granules, lobed nuclei, phagocytic – neutrophil: 50-70% – eosinophil: 0.5-3% – basophile: 0-1% • agranulocyte – lymphocyte: 20-30% – monocyte: 3-8% – Platelet (thrombocytes): 100-280×103 /µl 1. Blood components
2.Hematopoiesis bone marrow:formation of blood cells occurs mostly in red bone marrow in adult.All cells arise from same blood stem cell(pluripotent hematopoietic stem cell),then become colony- forming units(CFUs),precursor cells,and mature cell In certain cases,immature and/or abnormal forms of the cells may be present in the blood and may be detected with a blood differential,so further bone marrow aspiration may be necessary to give an accurate diagnosis(metastatic or hematological malignancies)
• bone marrow: formation of blood cells occurs mostly in red bone marrow in adult. All cells arise from same blood stem cell (pluripotent hematopoietic stem cell), then become colonyforming units (CFUs), precursor cells, and mature cell • In certain cases, immature and/or abnormal forms of the cells may be present in the blood and may be detected with a blood differential, so further bone marrow aspiration may be necessary to give an accurate diagnosis (metastatic or hematological malignancies) 2. Hematopoiesis
2.Hematopoiesis 98T Corcensted Firculating lod Proerythroblast Erythroblast Normoblast Reticulocyte Erythrocyte Platelets Megakaryoblast Megakaryocyte Neutrophilic myelocyte Neutrophil Myeloblast Eosinophilic myelocyte Hemocytoblas Basophilic myelocyte Basophil Monoblast Monocyte progenitor (ymghsbias T lymphocyte B progenitor &R85e8 B lymphocyte
2. Hematopoiesis
3.Blood function protection inflammation 一 limit spread of infection destroy microorganisms and cancer cells neutralize toxins initiate clotting ● transport:nutrients,oxygen,carbon dioxide, hormones,enzymes,etc regulation:regulates fluid balance,acid-base balance,the temperature of the body
3. Blood function • protection – inflammation – limit spread of infection – destroy microorganisms and cancer cells – neutralize toxins – initiate clotting • transport: nutrients, oxygen, carbon dioxide, hormones, enzymes, etc • regulation: regulates fluid balance, acid-base balance, the temperature of the body